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An Optimized Two-Herb Chinese Food as Medicine Formula Reduces Cisplatin-Induced Nephrotoxicity in the Treatment of Lung Cancer in Mice.
Front Pharmacol
March 2022
Laboratory of Natural Medicine and Molecular Engineering, College of Plant Science and Technology, National and Local Joint Engineering Research Center for Medicinal Plant Breeding and Cultivation, Hubei Provincial Engineering Research Center for Medicinal Plants, Innovation Academy of International Traditional Chinese Medicinal Materials, Huazhong Agricultural University, Wuhan, China.
Chemotherapy is considered a most effective way to treat cancer. However, it is very common that chemotherapy causes unbearable mental and physical side effects to cancer patients, which ultimately reduces the patients' confidence of overcoming diseases and compromises the treatment of chemotherapy. Cisplatin (DDP), a widely used anticancer agent for various types of cancers, also damages nontumor cells and tissues, which are mostly related to the activation of the inflammation pathway.
View Article and Find Full Text PDFA two-herb formula inhibits hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes.
Sci Rep
February 2021
Research and Development Centre for Natural Health Products, HKBU Shenzhen Research Institute and Continuing Education, Shenzhen, China.
Fibroblast-like synoviocytes (FLS) play a pathogenic role in rheumatoid arthritis (RA). STAT3 signaling is activated in FLS of RA patients (RA-FLS), which in turn causes RA-FLS hyperproliferation. RL is a traditional remedy for treating inflammatory diseases in China.
View Article and Find Full Text PDFA two-herb formula inhibits STAT3 signaling and exerts anti-melanoma effects in cell and animal models.
J Ethnopharmacol
March 2021
Center for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China; Research and Development Centre for Natural Health Products, HKBU Shenzhen Research Institute and Continuing Education, Shenzhen, China. Electronic address:
Ethnopharmacological Relevance: Malignant melanoma is a fatal cancer. Signal transducer and activator of transcription 3 (STAT3) has been proposed as a therapeutic target of melanoma. An herbal formula Huai-Hua-San (HHS) comprising Sophorae Flos (SF) and Gardeniae Fructus (GF) is traditionally used for treating cancers including melanoma, but the pharmacological basis is unknown.
View Article and Find Full Text PDFCorrigendum to "A two-herb formula inhibits osteoclastogenesis and suppresses NF-kB and MAPK pathways" [Journal of Ethnopharmacology 252 (2020) 112,625].
J Ethnopharmacol
January 2021
Research and Development Centre for Natural Health Products, HKBU Shenzhen Research Institute and Continuing Education, Shenzhen, China; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong. Electronic address:
An herbal formula inhibits STAT3 signaling and attenuates bone erosion in collagen-induced arthritis rats.
Phytomedicine
May 2020
Research and Development Centre for Natural Health Products, HKBU Shenzhen Research Institute and Continuing Education, Shenzhen, China; Centre for Cancer and Inflammation Research, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; Consun Chinese Medicines Research Centre for Renal Diseases, School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China; JaneClare Transdermal TCM Therapy Laboratory, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China. Electronic address:
Background: Receptor activator of NF-κB ligand (RANKL) facilitates differentiation of osteoclast precursors into osteoclasts, resulting in bone erosion in rheumatoid arthritis (RA) patients. Fibroblast-like synoviocytes (FLS) are the main cells for producing RANKL. Signal transducer and activator of transcription 3 (STAT3) signaling is activated in FLS of RA patients (RA-FLS), which has been linked to RANKL production.
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