Background: Skin cancer is one of the most common forms of cancers among humans. It can be classified as non-melanoma and melanoma. Although melanomas are less common than non-melanomas, the former is the most common cause of mortality. Therefore, it becomes necessary to develop a Computer-aided Diagnosis (CAD) aiming to detect this kind of lesion and enable the diagnosis of the disease at an early stage in order to augment the patient's survival likelihood.
Aims: This paper aims to develop a simple method capable of detecting and classifying skin lesions using dermoscopy images based on ABCD rules.
Methods: The proposed approach follows four steps. 1) The preprocessing stage consists of filtering and contrast enhancing algorithms. 2) The segmentation stage aims at detecting the lesion. 3) The feature extraction stage based on the calculation of the four parameters which are asymmetry, border irregularity, color and diameter. 4) The classification stage based on the summation of the four extracted parameters multiplied by their weights yields the total dermoscopy value (TDV); hence, the lesion is classified into benign, suspicious or malignant. The proposed approach is implemented in the MATLAB environment and the experiment is based on PH2 database containing suspicious melanoma skin cancer.
Results And Conclusion: Based on the experiment, the accuracy of the developed approach is 90%, which reflects its reliability.
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http://dx.doi.org/10.2174/1573405614666180911120546 | DOI Listing |
Am J Clin Oncol
January 2025
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY.
Objectives: Cutaneous adnexal carcinomas (CACs) are rare skin cancers with no established treatment guidelines. Given the limited data, this study aims to explore the characteristics and outcomes of patients with CAC treated with radiation therapy (RT).
Methods: Patients diagnosed with CAC between 2000 and 2020 who received RT were included.
Health Psychol Behav Med
January 2025
Department of Psychology, Northumbria University, Newcastle upon Tyne, UK.
Background: Sunburn and intermittent sun exposure elevate melanoma skin cancer risk. Sun protection behaviours, including limiting sun exposure, seeking shade, wearing protective gear, and using sunscreen, help mitigate excessive sun exposure. Smartphone apps present a promising platform to enhance these behaviours.
View Article and Find Full Text PDFPlast Reconstr Surg Glob Open
January 2025
From the Department of Plastic Surgery, Hull University Teaching Hospitals, East Riding of Yorkshire, United Kingdom.
Biodegradable temporizing matrix (BTM) is a synthetic biodegradable dermal matrix that helps develop a non-skin graft amenable wound bed (eg, over tendon or bone) into a graftable wound bed, by acting as an inert scaffold for angiogenesis and formation of granulation tissue. There is currently a paucity of evidence to encourage its use in scalp defects following skin malignancy excision. This retrospective analysis aimed to evaluate the utility of BTM in this patient subset.
View Article and Find Full Text PDFPostepy Dermatol Alergol
December 2024
Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, Krakow, Poland.
Psoriasis and psoriatic arthritis are chronic inflammatory conditions that constitute a significant global health burden due to their prevalence and impact on quality of life. A deeper comprehension of psoriasis and psoriatic arthritis pathogenesis has recently led to the emergence of novel classes of biologics targeting the IL-23/Th17 pathway. The specific role of interleukin-12, -23, and -17 in cancer as either promoters or inhibitors is under investigation in various studies.
View Article and Find Full Text PDFCancer Metab
January 2025
Department of Dermatology, Venereology and Allergology, University Medical Center and Medical Faculty Mannheim, Heidelberg University, Theodor-Kutzer-Ufer 1-3, Mannheim, 68167, Germany.
Background: In malignant melanoma, liver metastases significantly reduce survival, even despite highly effective new therapies. Given the increase in metabolic liver diseases such as metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH), this study investigated the impact of liver sinusoidal endothelial cell (LSEC)-specific alterations in MASLD/MASH on hepatic melanoma metastasis.
Methods: Mice were fed a choline-deficient L-amino acid-defined (CDAA) diet for ten weeks to induce MASH-associated liver fibrosis, or a CDAA diet or a high fat diet (HFD) for shorter periods of time to induce early steatosis-associated alterations.
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