AI Article Synopsis
- Gene therapy shows promise for treating cancers and hereditary diseases, but the effective delivery of nucleic acids like DNA and siRNA is challenging due to their degradation in the body.
- Currently, delivery vectors are categorized into viral (high efficiency but safety concerns) and non-viral (lower immunogenicity and easier to produce).
- The review evaluates existing delivery systems and highlights a new delivery method using RNTs, detailing their properties, delivery process, and current applications.
Article Abstract
Gene therapy has broad prospects as an effective treatment for some cancers and hereditary diseases. However, DNA and siRNA are easily degraded in vivo because of their biological activities as macromolecules, and they need the effective transmembrane delivery carrier Selecting the appropriate carrier for delivery will allow nucleic acid molecules to reach their site of action and enhance delivery efficiency. Currently used nucleic acid delivery vectors can be divided into two major categories: viral and non-viral vectors. Viral carrier transport efficiency is high, but there are safety issues. Non-viral vectors have attracted attention because of their advantages such as low immunogenicity, easy production, and non-tumorigenicity. The construction of safe, effective, and controllable vectors is the focus of current gene therapy research. This review presents the current types of nucleic acid delivery vehicles, which focuses on comparing their respective advantages and limitations, and proposes a novel delivery system, RNTs, a novel nanomolecular material, introducing the characteristics and nucleic acid delivery process of RNTs and their latest applications.
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| http://dx.doi.org/10.1007/s10544-020-0469-7 | DOI Listing |
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