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Impact of Oxidized Phosphatidylcholine Supplementation on the Lipidome of RAW264.7 Macrophages.
Arch Biochem Biophys
March 2025
Mass Spectrometry Center, LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, Santiago University Campus, 3810-193 Aveiro, Portugal. Electronic address:
Oxidized phospholipids (OxPLs) have emerged as critical damage-associated molecular patterns (DAMPs) and modulators of numerous biological processes, including inflammation, playing a significant role in health and disease. Despite their recognized influence on macrophage polarization, the precise mechanisms by which distinct OxPL species shape macrophage behavior remains poorly understood. The present study investigates the impact of two oxidized phosphatidylcholines (OxPC): omega 3 1-stearoyl-2-docosahexaenoyl-sn-glycero-3-phosphatidylcholine (OxPC22:6), and omega 6 1-stearoyl-2-linoleoyl-sn-glycero-3-phosphatidylcholine (OxPC18:2), on the lipidomic profile of RAW264.
View Article and Find Full Text PDFCarboxylesterase 2A gene knockout or enzyme inhibition alleviates steatohepatitis in rats by regulating PPARγ and endoplasmic reticulum stress.
Free Radic Biol Med
March 2025
Changning Maternity and Infant Health Hospital and School of Life Sciences, Shanghai Key Laboratory of Regulatory Biology, East China Normal University, Shanghai, China. Electronic address:
Metabolic dysfunction associated steatotic liver disease (MASLD) is a widespread liver disease that progresses from simple steatosis to severe steatohepatitis stage. Despite the recognized importance of carboxylesterase 2 (CES2) in hepatic lipid metabolism, the role of CES2 in hepatic inflammation remains unclear. The rat genome encodes six Ces2 genes and Ces2a shows high expression in liver and intestine.
View Article and Find Full Text PDFEffects of reheat treatment on warmed-over flavor and lipid oxidation in bowl-steamed Tan lamb.
Food Chem
March 2025
College of Food and Chemical Engineering, Liuzhou Institute of Technology, Liuzhou, Guangxi 545616, China.
The warmed-over flavor (WOF) can significantly impair the flavor quality of prepared foods, leading to reduced consumer acceptance. This study investigates the molecular composition of WOF and the alterations in lipid molecules during the heating-cooling-reheating process of bowl-steamed Tan lamb, employing a comprehensive analytical approach. By integrating GC-MS and GC-IMS analyses, 11 WOF-related compounds were identified, including furan, 2-pentyl-, and 2-pentanone.
View Article and Find Full Text PDFPlasma Lipidomics of Preadolescent Children: A Hokkaido Study.
J Lipids
February 2025
Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo, Japan.
Lipids are the most abundant biomolecules of human plasma, and their balance plays a significant role in health and disease management. Despite the importance of lipids, the studies focused on the comprehensive determination of the plasma lipidome in children are limited. In this study, we investigated the sex, age, and weight-specific changes in the plasma lipidome of nonfasting preadolescent children aged 9-12 years ( = 342) using a nontargeted liquid chromatography-mass spectrometry technique.
View Article and Find Full Text PDFMetabolomic and lipidomic profiling reveals convergent pathways in attention deficit hyperactivity disorder therapeutics: Insights from established and emerging treatments.
J Pharmacol Exp Ther
February 2025
3Z, Reykjavik, Iceland; Department of Engineering, Reykjavik University, Reykjavik, Iceland; Medical Department, School of Health Sciences, University of Iceland, Reykjavik, Iceland. Electronic address:
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with unclear pathological mechanisms. ADHD is treated with both stimulant and nonstimulant medications, but their therapeutic mechanisms and impact on brain metabolites are not fully understood. This study employed an untargeted metabolomics approach with liquid chromatography mass spectrometry to investigate the pathogenesis of ADHD, as well as the effects of established and novel therapeutics.
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