Association of Cirrhosis and Cardiomyopathy.

Euroasian J Hepatogastroenterol

Department of Gastroenterology, Harran University, Sanliurfa, Turkey.

Published: January 2019

AI Article Synopsis

  • The study explored the relationship between pro-BNP, troponin-I, ECG, and ECHO measurements in diagnosing cirrhotic cardiomyopathy in patients with liver cirrhosis.
  • Thirty compensated cirrhotic patients, thirty decompensated cirrhotic patients, and thirty controls were analyzed using ECHO, ECG, and blood tests for troponin-I and pro-BNP levels.
  • Results indicated that pro-BNP levels and QTc intervals were significantly elevated in both compensated and decompensated cirrhotic groups compared to controls, suggesting a correlation between higher pro-BNP levels and the severity of cirrhosis-related cardiomyopathy.

Article Abstract

Introduction: We investigated association of pro-BNP, troponin-I, electrocardiography (ECG) and echocardiography (ECHO) during diagnosis and identification of cirrhotic cardiomyopathy in cirrhotic patients.

Materials And Methods: Patients were divided into three groups as; compensated cirrhotic patients (group 1, n= 30), decompensated cirrhotic (group 2, n = 30) and control group (group 3, n = 30). ECHO, and ECG were performed, and troponin-I and levels of pro-BNP were analyzed.

Results: Average age of group 1 was 46.36 ± 16 years (range 19-86), 60% were female; group 2 was 57.03 ± 13.54 years (range 22-89), 56% female; and group 3 was 49.13 ± 0.95 years (range 18-80), 56% female. A significant increase in QTc was detected in compensated cirrhotic patients compared to the control group (p <0.05). Pro-BNP levels were significantly higher (p <0.05) in the compensated cirrhotic group compared to the control group. The levels of pro-BNP were also significantly higher in the decompensated cirrhotic group compared compensated cirrhosis group and control group (p <0.001).

Conclusion: The increase of pro-BNP levels with severity of the disease in cirrhotic patients and the prolongation of QTc interval supports an association between these factors with cardiomyopathy.

How To Cite This Article: Sezgin B, Cindoglu C, et al. Association of Cirrhosis and Cardiomyopathy. Euroasian J Hepatogastroenterol 2019;9(1):23-26.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969323PMC
http://dx.doi.org/10.5005/jp-journals-10018-1291DOI Listing

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