AI Article Synopsis
- Dendrites and glial cells interact closely during development, but the specific molecules coordinating their formation are largely unknown.
- The study focuses on neurons BAG and URX, which attach to a single glial cell in the nose, providing insights into dendrite-glia relationships similar to those in mammalian brains.
- Researchers discovered that the adhesion protein SAX-7 and the protein GRDN-1 are crucial for dendrite growth, with SAX-7 functioning in both neurons and glia, and GRDN-1 promoting growth non-autonomously from glial cells.
Article Abstract
Dendrites develop elaborate morphologies in concert with surrounding glia, but the molecules that coordinate dendrite and glial morphogenesis are mostly unknown. offers a powerful model for identifying such factors. Previous work in this system examined dendrites and glia that develop within epithelia, similar to mammalian sense organs. Here, we focus on the neurons BAG and URX, which are not part of an epithelium but instead form membranous attachments to a single glial cell at the nose, reminiscent of dendrite-glia contacts in the mammalian brain. We show that these dendrites develop by retrograde extension, in which the nascent dendrite endings anchor to the presumptive nose and then extend by stretching during embryo elongation. Using forward genetic screens, we find that dendrite development requires the adhesion protein SAX-7/L1CAM and the cytoplasmic protein GRDN-1/CCDC88C to anchor dendrite endings at the nose. SAX-7 acts in neurons and glia, while GRDN-1 acts in glia to non-autonomously promote dendrite extension. Thus, this work shows how glial factors can help to shape dendrites, and identifies a novel molecular mechanism for dendrite growth by retrograde extension.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044450 | PMC |
| http://dx.doi.org/10.1242/dev.180448 | DOI Listing |
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