AI Article Synopsis
- Vulval cancer is uncommon, and Bartholin gland carcinomas account for less than 5% of these cases, posing challenges for diagnosis and treatment.
- A 55-year-old woman was found to have a vulval lesion in the Bartholin gland with characteristics of enteric type adenocarcinoma, showing positive immunohistochemical markers.
- No other primary cancer was identified, and the tumor was successfully excised with negative sentinel node results; genetic testing revealed no mutations that might inform future anti-EGFR therapies.
Article Abstract
Vulval cancer is rare. With Bartholin gland carcinomas representing <5% of all vulval carcinomas they present both diagnostic and management challenges. There are a small number of cases in the literature describing Bartholin gland carcinomas with unusual histology which necessitates the need to explore the possibility of metastases from elsewhere. We present a case of a 55-yr-old woman presenting with a vulval lesion within the Bartholin gland. Morphology demonstrated enteric type adenocarcinoma and the immunohistochemistry profile was positive for CK7, CK20, CDX2, CEA, and CA19-9. There was no evidence of an alternative primary cancer and the tumor was excised with negative regional sentinel node assessment. Genotyping showed no detectable mutations in KRAS, BRAF or NRAS suggesting a possible future role for anti-EGFR therapy.
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| http://dx.doi.org/10.1097/PGP.0000000000000667 | DOI Listing |
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