AI Article Synopsis
- The study aimed to examine the levels of Cyclin D1 and Ki-67 in both primary oral squamous cell carcinoma (OSCC) and its metastatic forms, focusing on various histological grades.
- Thirty samples were analyzed, revealing that primary OSCC patients had an average age of about 53, while those with metastasis were around 61, with males being more affected and the tongue being the most common site for tumors.
- Results showed a significant difference in Cyclin D1 expression between primary and metastatic OSCC, suggesting it may be a valuable marker for determining the aggressiveness and potential metastasis of the disease.
Article Abstract
Objective: The aim of current study was to investigate the expression of Cyclin D1 and Ki-67 in primary and metastatic oral squamous cell carcinoma (OSCC) and their different histological grades.
Methods: Paraffin embedded 30 oral squamous cell carcinoma (15 each of primary and cervical lymph node metastatic OSCC) were included in the study. Cyclin D1 and Ki 67 expressions were evaluated by immunohistochemistry and compared in primary and lymph node metastasis of OSCC and their histological grades. The data was analyzed using SPSS software.
Results: The mean age of patients with primary OSCC was 53.47 ±16.67 years and 61.47 ±11.94 years in patients with metastasis. Males were comparatively affected more than females with tongue as the most common site involved in both primary and metastatic tumours. The mean size of primary and metastatic tumour biopsies were 1.16 mm and 3.93 mm respectively. Comparison of the expression of Cyclin D1 in these primary and metastatic OSCC revealed a statistically significant difference (p = 0.003) whereas it was insignificant for Ki-67 (p = 0.715).
Conclusion: Cyclin D1 can be a useful marker in predicting aggressive or metastatic behaviour of OSCC on premier biopsies.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294039 | PMC |
| http://dx.doi.org/10.31557/APJCP.2020.21.1.37 | DOI Listing |
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