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Diplonemid protists possess exotic endomembrane machinery, impacting models of membrane trafficking in modern and ancient eukaryotes.
Curr Biol
March 2025
Division of Infectious Diseases, Department of Medicine, and Department of Biological Sciences, University of Alberta, 1-124 Clinical Sciences Building, 11350-83 Avenue, Edmonton, AB T6G 2G3, Canada; Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branišovská 1160/31, České Budějovice (Budweis) 370 05, Czech Republic; Centre for Life's Origin and Evolution, Division of Biosciences (Darwin Building), University College London, Gower Street, London WC1E 6BT, UK. Electronic address:
Diplonemids are among the most abundant and species-rich protists in the oceans. Marine heterotrophic flagellates, including diplonemids, have been suggested to play important roles in global biogeochemical cycles. Diplonemids are also the sister taxon of kinetoplastids, home to trypanosomatid parasites of global health importance, and thus are informative about the evolution of kinetoplastid biology.
View Article and Find Full Text PDFTreatment of Noncompressible Torso Hemorrhage With Thermoreversible Intra-abdominal Foam: A Dose-response Study in a Porcine Model.
J Surg Res
March 2025
Benchmark Biotech LLC, Portland, Oregon.
Introduction: Noncompressible torso hemorrhage (NCTH) leads to significant mortality in civilian settings where transport to a trauma center may be delayed and is also the leading cause of exsanguination on the battlefield. Fast Onset Abdominal Management (F.O.
View Article and Find Full Text PDFPredictive validity evidence of Yes-No Angoff standard setting in a Pre-Clinical medical school curriculum.
BMC Med Educ
March 2025
Associate Dean for Evaluation and Assessment, Mercer University School of Medicine, 1250 East 66th Street, Savannah, GA, 31404, USA.
Background: Standard setting plays a critical role in determining student outcomes by defining the level of biomedical knowledge required to be considered competent. This is especially important for accurately classifying medical students as ready (or not) to progress through the pre-clinical curriculum. In multiple-choice medical knowledge exams, the Yes-No Angoff method may be used for setting passing scores.
View Article and Find Full Text PDFSimilar failures of consideration arise in human and machine planning.
Cognition
March 2025
Department of Psychology, Harvard University, Cambridge, MA 02139, United States of America. Electronic address:
Humans are remarkably efficient at decision making, even in "open-ended" problems where the set of possible actions is too large for exhaustive evaluation. Our success relies, in part, on processes for calling to mind the right candidate actions. When these processes fail, the result is a kind of puzzle in which the value of a solution would be obvious once it is considered, but never gets considered in the first place.
View Article and Find Full Text PDFDevelopment a predictive nomogram for spontaneous pleurodesis in patients with non-small cell lung cancer and malignant pleural effusion.
J Thorac Dis
February 2025
Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, China.
Background: Indwelling pleural catheter (IPC) insertion is associated with fewer subsequent procedures and higher rates of spontaneous pleurodesis (SP) in patients with malignant pleural effusion (MPE). However, long-term pleural drains may cause psychological and physical distress. Additionally, only a portion of patients can benefit from IPC insertion and ultimately have them removed.
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