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| http://dx.doi.org/10.1073/pnas.1920300117 | DOI Listing |
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Nanopore sequencing reveals that DNA replication compartmentalisation dictates genome stability and instability in Trypanosoma brucei.
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University of Glasgow Centre for Parasitology, The Wellcome Centre for Integrative Parasitology, University of Glasgow, School of Infection and Immunity, Sir Graeme Davies Building, 120 University Place, Glasgow, G12 8TA, United Kingdom.
The Trypanosoma brucei genome is structurally complex. Eleven megabase-sized chromosomes each comprise a transcribed core flanked by silent subtelomeres, housing thousands of Variant Surface Glycoprotein (VSG) genes. Additionally, hundreds of sub-megabase chromosomes contain 177 bp repeats of unknown function, and VSG transcription sites localise to many telomeres.
View Article and Find Full Text PDFSilica-exposed patients with silicosis show shorter telomeres than do unexposed individuals: a pilot study in a population in southeastern Brazil.
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View Article and Find Full Text PDFIntegrated analysis of single-cell and bulk-RNA sequencing for the cellular senescence in prognosis of lung adenocarcinoma.
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Department of Thoracic Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Non-small cell lung cancer (NSCLC), half of which are lung adenocarcinoma (LUAD), is one of the most widely spread cancers in the world. Telomerase, which maintains telomere length and chromosomal integrity, enables cancer cells to avoid replicative senescence. When telomerase is inhibited, cancer cells' senescence began, preventing them from growing indefinitely.
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Article Synopsis
- The study focuses on developing a new prognostic model that combines telomere-related and aging-related gene signatures to predict outcomes for lung adenocarcinoma (LUAD) patients.
- By analyzing clinical data and patient samples through advanced statistical methods, the researchers identified eight key genes that are linked to LUAD prognosis.
- The findings suggest that the low-risk group shows better immune cell presence and may respond differently to certain cancer treatments, paving the way for personalized therapy approaches for LUAD.
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