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IGF-I levels during standard Lanreotide dose predicts biochemical outcome of high-frequency regimen in acromegaly.
Pituitary
December 2024
Institute of Endocrine and Metabolic Sciences, San Raffaele Vita-Salute University and IRCCS San Raffaele Hospital, Milan, Italy.
Introduction: First-generation somatostatin receptor ligands (fg-SRLs) are the cornerstone of acromegaly treatment. Additional benefits were shown using high dose (HD) or high frequency (HF), relatively short-term regimens. Although several predictors of response to standard dose (SD)-fg-SRLs were reported, outcome biomarkers for HF administration are not yet available.
View Article and Find Full Text PDFSpondyloarthritis and Risk of Malignancy: A Narrative Review on a Still Controversial Issue.
Rheumatol Ther
December 2024
University of Milan, Fondazione IRCCS Istituto Nazionale del Tumori, Milan, Italy.
Current literature regarding cancer risk in rheumatic and musculoskeletal diseases (RMDs) is particularly poor and controversial, even though the incidence of malignancy in some patients with RMDs is considered to be increased compared with the general population. Malignancy may be a major comorbidity in subjects with spondyloarthritis (SpA) as the result of multifactorial mechanisms, from disease pathogenesis to the iatrogenic effect of immunomodulating drugs. Several recommendations for screening and management of cancer risk have been developed in recent years with the aim of improving the different outcomes in these patients.
View Article and Find Full Text PDFImpact of different 2D materials on the efficacy of photothermal and photodynamic therapy in 3D-bioprinted breast cancer.
Nanoscale
December 2024
Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy.
The convergence of nanotechnology and tissue engineering has paved the way for innovative cancer treatments that leverage the unique light absorption properties of nanomaterials. Indeed, photothermal therapy (PTT) and photodynamic therapy (PDT) utilize nanomaterials to convert near-infrared light into therapeutic energy for cancer treatment. This study focuses on the application of poly(lactic--glycolic acid) (PLGA) scaffolds, enhanced by graphene oxide, TiCT MXene, and TiS transition metal dichalcogenides for PDT and PTT treatments evaluated within 3D-bioprinted breast cancers.
View Article and Find Full Text PDFResponse letter to the editor: "Is desmoplastic stromal reaction useful to modulate lymph node dissection in sporadic medullary thyroid carcinoma?".
Surgery
December 2024
UOC Chirurgia Endocrina e Metabolica, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy; Centro di Ricerca in Chirurgia delle Ghiandole Endocrine e dell'Obesità, Università Cattolica del Sacro Cuore, Rome, Italy.
Frailty, comorbidity, and multimorbidity and their relation with medications adherence in primary care older adults.
Eur Geriatr Med
December 2024
Italian College of General Practitioners and Primary Care, Florence, Italy.
Purpose: To assess and compare, through a retrospective cohort study, the relationships between frailty, comorbidity, multimorbidity, and levels of adherence to lipid-lowering drugs (LLDs), antihypertensives and antidepressants.
Methods: In a primary care database, we selected a cohort of patients aged 60 or older on December 31, 2022. The date of the first prescription of the aforementioned medications was the study index date.
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