Two new nor-sesquiterpenoids from , an endophytic fungus isolated from .

As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (-) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of , an endophytic fungus isolated from the root of . The structures of these two previously undescribed compounds were elucidated by interpretation of the spectroscopic evidences including NMR correlations as well as MS data. The absolute configurations of these two compounds were confirmed by TD-DFT-ECD calculations. An MTT assay indicated that compound exhibited moderate cytotoxic activity against MV4-11 with an IC value of 22.29 μM.