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Enhanced efficacy of brucine dissolving-microneedles as a targeted delivery system in rheumatoid arthritis treatment: a comprehensive pharmacokinetic-pharmacodynamic analysis.
Drug Deliv Transl Res
February 2025
School of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, China.
Article Synopsis
- Previous research demonstrated that brucine dissolving-microneedles (Bru-DMNs) effectively treat rheumatoid arthritis (RA) while addressing issues common with oral and systemic drug delivery.
- This study developed a novel method for continuous sampling and analysis of drug distribution in RA rats, revealing that Bru-DMNs achieve better retention in joint cavities than in blood.
- The findings highlight a complex PK-PD relationship for Bru against RA, offering insights into how transdermal drugs may work and their potential side effects.
Toxicokinetics of thebaine in those consuming non-food grade poppy seeds as a tea.
Clin Toxicol (Phila)
September 2023
Edith Collins Centre, Drug Health Services, Royal Prince Alfred Hospital, Camperdown, Australia.
Introduction: Thebaine is an alkaloid in poppy seeds that is neurotoxic to animals. Data on its clinical effects and toxicokinetics in people are minimal. In 2022, poppy seeds high in thebaine entered the Australian food market, and people consuming tea made from these poppy seeds developed poisoning.
View Article and Find Full Text PDFRapid determination of five common toxic alkaloids in blood by UPLC-MRM-IDA-EPI: Application to poisoning case.
Leg Med (Tokyo)
July 2023
Department of Forensic Medicine, Guizhou Medical University, Guiyang, Guizhou 550004, PR China; Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, Guizhou Medical University, Guiyang 550004, PR China. Electronic address:
Toxic alkaloids are typically found in herbal medicines and have strong pharmacological effects and a broad therapeutic spectrum. On the other hand, toxic alkaloids exert toxicological activities in vivo; as such they have a narrow therapeutic window and can induce poisoning due to incorrect dose or misuse. In this view, there is an urgent need to develop a rapid and sensitive assay to detect these toxic alkaloids.
View Article and Find Full Text PDFConformational transitions and allosteric modulation in a heteromeric glycine receptor.
Nat Commun
March 2023
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, 44106-4970, USA.
Glycine Receptors (GlyRs) provide inhibitory neuronal input in the spinal cord and brainstem, which is critical for muscle coordination and sensory perception. Synaptic GlyRs are a heteromeric assembly of α and β subunits. Here we present cryo-EM structures of full-length zebrafish α1βGlyR in the presence of an antagonist (strychnine), agonist (glycine), or agonist with a positive allosteric modulator (glycine/ivermectin).
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