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Ultrasensitive, Real-Time Detection of Viral Antigens and RNA Enabled by Scalable Graphene-Based FET Sensors for Pathogen Detection: A Case Study on COVID-19.
ACS Sens
March 2025
Centre for Innovative Materials for Health, School of Chemical Sciences, The University of Auckland, 23 Symonds Street, Auckland 1010, New Zealand.
Herein, a novel and simple electrospray (ES) printing technique was developed for the fabrication of ultrathin graphene layers with precisely controlled nanometer-scale thickness, where graphene oxide (GO) was electrosprayed on wafers and subsequently chemically reduced into reduced GO (rGO). Utilizing that technique, we prepared ultrathin rGO in-plane graphene field-effect transistor (GFET)-based biosensors coupled with a portable prototype measuring system for point-of-care detection of pathogens. We illustrate the use of such prepared GFETs to detect COVID-19, using the SARS-CoV-2 nucleocapsid protein antigen (N-protein) and genomic viral RNA as detection targets.
View Article and Find Full Text PDFSignificant Tumor Inhibition of Trimethyl-152-[L-aspartyl]pheophorbide a in Tumor Photodynamic Therapy‡.
ChemMedChem
March 2025
Donghua University, Pharmaceutical Science & Technology, CHINA.
A novel pheophorbide derivative, trimethyl-152-[L-aspartyl]pheophorbide a was synthesised and investigated for anti-tumor activity. The prepared photosensitizer had good absorption in the phototherapeutic window and high ROS yields. It exhibited excellent phototoxicity higher than reference compound m-THPC when irradiated by 650 nm light in vitro, and obvious photodynamic anti-tumor effect in vivo.
View Article and Find Full Text PDFEffectiveness of Grief Camps in Supporting Bereaved Individuals: A Systematic Review.
Omega (Westport)
March 2025
Centre for Mental Health and Community Wellbeing, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Experiencing the death of a loved one is a stressful and disruptive event that can have short-term and long-term detrimental effects on the grief, mental health, and social functioning of the bereaved individuals. Grief camps represent a relatively novel form of support. However, little is known about their effectiveness.
View Article and Find Full Text PDFTargeting IL-23 in Psoriatic Arthritis: A Review of Guselkumab's Efficacy and Utilization.
Skin Therapy Lett
March 2025
Center for Clinical Studies, Webster, TX, USA.
Psoriatic arthritis (PsA) is a chronic, inflammatory disease with heterogeneous clinical features. The pathogenesis of PsA involves a complex interplay of genetic, immunologic, and environmental factors, leading to the activation of the immune system and subsequent inflammation. Over the past decade, the understanding of the immune mechanisms underlying PsA has advanced significantly, particularly regarding the role of the interleukin-23/T helper 17 pathway in the disease process.
View Article and Find Full Text PDFHigh-performance magnesium organic batteries using renewable biomolecule-based cathode.
Chemistry
March 2025
Chongqing University, College of Materials Science and Engineering, CHINA.
Rechargeable magnesium batteries (RMBs) exhibit significant potential in large-scale energy storage due to their features of high volumetric capacity, resistance to dendrite formation, and abundant magnesium resources. However, the high polarity of divalent Mg2+ ions results in sluggish diffusion kinetics in conventional inorganic cathode materials, adversely affecting reversible capacity and rate performance. Organic materials such as pyrene-4,5,9,10-tetrone (PTO) and 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA), achieve rapid and reversible intercalation of magnesium ions through carbonyl enolization, but these materials are challenged by high cost, complex preparation, and poor environmental friendliness.
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