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Mass Spectrometry-Based Workflow for the Identification and Quantification of Alternative and Canonical Proteins in Pancreatic Cancer Cells.
Cells
November 2024
Laboratoire de Recherche en Sciences Végétales (LRSV), CNRS/UT3/INPT, 31320 Auzeville-Tolosane, France.
The identification of small proteins and proteins produced from unannotated open reading frames (called alternative proteins or AltProts) has changed our vision of the proteome and has attracted more and more attention from the scientific community. Despite several studies investigating particular AltProts in diseases and demonstrating their importance in such context, we are still missing data on their expression and functions in many pathologies. Among these, pancreatic ductal adenocarcinoma (PDAC) is a particularly relevant case to study alternative proteins.
View Article and Find Full Text PDFInceptor binds to and directs insulin towards lysosomal degradation in β cells.
Nat Metab
December 2024
Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Zentrum München, Neuherberg, Germany.
Blunted first-phase insulin secretion and insulin deficiency are indicators of β cell dysfunction and diabetes manifestation. Therefore, insights into molecular mechanisms that regulate insulin homeostasis might provide entry sites to replenish insulin content and restore β cell function. Here, we identify the insulin inhibitory receptor (inceptor; encoded by the gene IIR/ELAPOR1) as an insulin-binding receptor that regulates insulin stores by lysosomal degradation.
View Article and Find Full Text PDFHealth Needs and Priorities of an Underserved Karenni Refugee Community: A Community Needs Assessment.
N C Med J
June 2024
Department of Family and Community Medicine, School of Medicine, Wake Forest University.
Background: Southeast Asian refugee communities are frequently underserved by social and medical systems and experience profound health and health care inequities. The purpose of this study was to detail the health needs, priorities, and health care utilization of the Karenni, a Southeast Asian refugee community, in Forsyth County, North Carolina.
Methods: A mixed-mode survey (i.
Detection of Borrelia burgdorferi sensu lato by proteomics: a complementary diagnosis tool on erythema migrans biopsies.
Clin Microbiol Infect
January 2025
UR3073-Pathogen-Host- Arthropod Vectors Interactions-Group Borrelia, Fédération de Médecine Translationnelle, Université de Strasbourg, Strasbourg, France; French National Reference Center for Borrelia, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:
Objectives: We have developed targeted proteomics in the context of Lyme borreliosis (LM) as a new direct diagnostic tool for detecting Borrelia proteins in the skin of patients with erythema migrans. If satisfactory, this proteomic technique could be used in addition to culture and/or PCR for disseminated infections where Borrelia detection is essential to demonstrate active infection. In these infections, the diagnosis is indirect and relies mainly on serology.
View Article and Find Full Text PDFWomen with polycystic ovary syndrome are at risk of emotional and uncontrolled eating at midlife: a population-based cohort study.
Fertil Steril
September 2024
Department of Obstetrics and Gynecology, Research Unit of Clinical Medicine, University of Oulu and Oulu University Hospital, Oulu, Finland; Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. Electronic address:
Objective: To investigate eating behavior domains-emotional, uncontrolled, and cognitive restraint eating-in women with polycystic ovary syndrome (PCOS) with different PCOS phenotypes and women without PCOS at midlife.
Design: A prospective cohort study. Eating behavior domains were assessed at age of 46 years.
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