Three new polyketides, ketidocillinones A-C (-), were discovered from the extract of an Antarctica sponge-derived fungus sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound was established by using ECD calculation. Compounds - can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C ( and ) exhibited potent antibacterial activity against , and MRCNS (methicillin-resistant coagulase-negative ) with MIC values ranging from 1.56 to 25.00 µg/mL.
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| http://dx.doi.org/10.3390/md18020071 | DOI Listing |
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