The effect of norepinephrine, histamine, serotonin and potassium chloride on electrogenesis and contraction was studied on innervated and denervated smooth muscles of cat's nictitating membrane. Denervated smooth muscles generate slow depolarizing potentials with the APs corresponding to tonic and phasic contractions, resp. Tonic contractions occur with no considerable change fo the MP in innervated muscles, phasic contractions being absent. Spontaneous generation of the APs is only possible in denervated muscles. Pharmacomechanical type of coupling between excitation and contraction seems to be characteristic of innervated smooth muscles, whereas electromechanical type is characteristic of denervated muscles. The denervation seems to result not only in the change of cells' sensitivity to transmitters but in the abnormality of coupling processes between excitation and contraction as well.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Harnessing the regenerative effects of human amniotic stem cells (hAFSCs) on restoring erectile function in a bilateral cavernous nerve crush (BCNC) injury rat model.
Stem Cell Res Ther
November 2024
School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City, 242062, Taiwan.
Background: Intracavernous (IC) injections of stem cells has been shown to ameliorate cavernous nerve (CN)-induced erectile dysfunction (ED). However, the regenerative effects underlying the recovery of erectile function (EF) in human amniotic fluid-derived stem cells (hAFSCs) remain unclear. In the bilateral cavernous nerve crushing (BCNC) injury rat paradigm, we sought to ascertain the effects of hAFSC treatment on EF recovery during the incipient phase.
View Article and Find Full Text PDFSuperior cervical ganglionectomy attenuates vascular remodeling in spontaneously hypertensive rats.
J Hypertens
February 2025
Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, and Department of Physiology.
Article Synopsis
- The study investigates the role of excessive sympathetic activity in causing vascular remodeling in hypertension by performing local sympathetic denervation through superior cervical ganglionectomy (SCGx) on two types of rats: Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR).
- Results showed that SCGx did not significantly affect blood pressure or heart rate but reduced vascular remodeling in specific arteries associated with the sympathetic nervous system, while it had minimal impact on non-sympathetic arteries.
- The findings suggest that sympathetic overactivity is a key factor in vascular changes associated with hypertension, as evidenced by improvements in blood flow and reduced oxidative stress and inflammation in denervated arteries of SHR
Mechanism of denervation muscle atrophy mediated by Ach/p38/MAPK pathway in rats with erectile dysfunction caused by nerve injury.
Exp Cell Res
October 2024
Department of Anesthesiology, the First Affiliated Hospital of Zhejiang University School of Medicine Zhejiang, China. Electronic address:
Background: Peripheral nerve injury can result in penile cavernosal denervation muscle atrophy, a primary factor in nerve injury erectile dysfunction (NED). While acetylcholine (Ach) is integral to erectile function, its role and mechanisms in NED need further exploration.
Objective: To investigate the inhibition of CCMSCs Apoptosis and Protein Degradation Pathway by Ach in NED rat model.
Interventional pulmonology for chronic inflammatory airway diseases.
Chin Med J Pulm Crit Care Med
September 2024
Pneumology and Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg 69126, Germany.
Article Synopsis
- - Chronic inflammatory airway diseases like chronic bronchitis, COPD, emphysema, and asthma are significant healthcare issues that can be addressed with interventional treatments alongside standard medical therapy.
- - These minimally invasive procedures, such as bronchial thermoplasty and lung volume reduction techniques, directly target the airways to relieve symptoms and improve lung function by reducing hyperinflation and mucus production.
- - The review provides insights into various interventional methods based on specific disease types, helping pulmonologists choose the best treatment options for their patients.
IL-17A exacerbates corpus cavernosum fibrosis and neurogenic erectile dysfunction by inducing CSMC senescence via the mTORC2-ACACA pathway.
BMC Med
September 2024
Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Tianhe Road 600, Guangzhou, 510630, China.
Background: Neurogenic erectile dysfunction, characterized by neurological repair disorders and progressive corpus cavernosum fibrosis (CCF), is an unbearable disease with limited treatment success. IL-17A exhibits a complex role in tissue remodelling. Nevertheless, the precise role and underlying mechanisms of IL-17A in CCF under denervation remain unclear.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!