Blind Source Separation for Myelin Water Fraction Mapping Using Multi-Echo Gradient Echo Imaging.

In conventional gradient-echo myelin water imaging (GRE-MWI), myelin water fraction (MWF) is estimated by fitting the multi-echo gradient recalled echo (mGRE) signal to a pre-assumed numerical model (e.g., multi-component exponential curves or three component exponential curves). However, in mGRE, imaging artifacts (e.g., voxel spread function and physiological noise) and noise render the signal to deviate from the numerical model, leading to misfit of the model parameters. Here, as an alternative to the model-based GRE-MWI, a blind source separation (BSS) technique for the separation of multi-exponential mGRE signal is proposed. Among the various BSS techniques, a modified robust principal component analysis (rPCA) is presented to separate signal sources by enforcing the data-driven properties such as "low rankness" and "sparsity." Considering the signal evolution of T relaxation (i.e., non-negative exponential decay), low rankness of exponential decay was enforced by nonnegative matrix factorization (NMF) and hankelization. This method provides the separation of slow-decaying, fast-decaying exponential components and artifact components from mGRE images. After the separation, MWF map is reconstructed as the ratio of the fast-decaying component to the total decaying components. The proposed method was demonstrated in numerical simulations and in vivo scans. The method provided a robust estimation of MWF in the presence of statistical noise and imaging artifacts.