A bacterial Goldilocks mechanism.

Elife

College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, United States.

Published: January 2020

can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299333PMC
http://dx.doi.org/10.7554/eLife.54244DOI Listing

Publication Analysis

Top Keywords

bacterial goldilocks
4
goldilocks mechanism
4
mechanism measure
4
measure activity
4
activity enzymes
4
enzymes remodel
4
remodel cell
4
cell wall
4
wall ensure
4
ensure levels
4

Similar Publications

Antimicrobial peptides (AMPs) are generally membrane-active compounds that physically disrupt bacterial membranes. Despite extensive research, the precise mode of action of AMPs is still a topic of great debate. This work demonstrates that the initial interaction between the Gram-negative and AMPs is driven by lipopolysaccharides (LPS) that act as kinetic barriers for the binding of AMPs to the bacterial membrane.

View Article and Find Full Text PDF

Oxygen levels in vivo are autonomously regulated by a supply-demand balance, which can be altered in disease states. However, the oxygen levels of in vitro cell culture systems, particularly microscale cell culture, are typically dominated by either supply or demand. Further, the oxygen microenvironment in these systems is rarely monitored or reported.

View Article and Find Full Text PDF
Article Synopsis
  • Resistance-nodulation-division (RND) efflux pumps play a crucial role in how bacteria develop resistance to antibiotics.
  • The study utilized evolutionary analyses, structural modeling, and ligand docking to explore differences in how two specific RND transporters, MexY and MexB, select their antibiotic substrates.
  • The concept of "Goldilocks affinity" is introduced, suggesting that antibiotics must bind at just the right level—strong enough to interact with the pump but not so tight that they prevent efficient transport.
View Article and Find Full Text PDF

A bacterial Goldilocks mechanism.

Elife

January 2020

College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, United States.

can measure the activity of the enzymes that remodel the cell wall to ensure that the levels of activity are 'just right'.

View Article and Find Full Text PDF

In radiating populations of SBW25, adaptive wrinkly spreader (WS) mutants are able to gain access to the air-liquid (A-L) interface of static liquid microcosms and achieve a significant competitive fitness advantage over other non-biofilm-forming competitors. Aerotaxis and flagella-based swimming allows SBW25 cells to move into the high-O region located at the top of the liquid column and maintain their position by countering the effects of random cell diffusion, convection and disturbance (i.e.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!