Cocaine detection using aptamer and molybdenum disulfide-gold nanoparticle-based sensors.

The current work highlighted a novel colorimetric sensor based on aptamer and molybdenum disulfide (MoS)-gold nanoparticles (AuNPs) that was developed for cocaine detection with high sensitivity. Due to the presence of the plasmon resonance band on the surface of AuNPs, AuNPs aggregated and the color was changed from red to blue after adding a certain concentration of NaCl. We used MoS to optimize the sensing system of AuNPs. The folded conformation of the aptamer in combination with cocaine enhanced the salt tolerance of the MoS-AuNPs, effectively preventing their aggregation. The detection limit of cocaine was 7.49 nM with good selectivity. The method based on MoS-AuNPs colorimetry sensor is simple, quick, label-free and low cost.