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Chemical Logic of Peptide Branching by Iterative Nonlinear Nonribosomal Peptide Synthetases.
Biochemistry
January 2025
Department of Chemistry, Washington University in St. Louis, One Brookings Drive, St. Louis, Missouri 63130, United States.
Branch-point syntheses in nonribosomal peptide assembly are rare but useful strategies to generate tripodal peptides with advantageous hexadentate iron-chelating capabilities, as seen in siderophores. However, the chemical logic underlying the peptide branching by nonribosomal peptide synthetase (NRPS) often remains complex and elusive. Here, we review the common strategies for the biosynthesis of branched nonribosomal peptides (NRPs) and present our biochemical investigation on the NRPS-catalyzed assembly of fimsbactin A, a branched mixed-ligand siderophore produced by the human pathogenic strain .
View Article and Find Full Text PDFIdentification of Biomarkers Related to Liquid-Liquid Phase Separation for Ulcerative Colitis Based on Single-Cell and Bulk RNA Transcriptome Sequencing Data.
Endocr Metab Immune Disord Drug Targets
January 2025
Department of Radiotherapy, Suzhou Ninth People's Hospital, Suzhou, 215200, China.
Background: Liquid-Liquid Phase Separation (LLPS) is a process involved in the formation of established organelles and various condensates that lack membranes; however, the relationship between LLPS and Ulcerative Colitis (UC) remains unclear.
Aims: This study aimed to comprehensively clarify the correlation between ulcerative colitis (UC) and liquid-liquid phase separation (LLPS).
Objectives: In this study, bioinformatics analyses and public databases were applied to screen and validate key genes associated with LLPS in UC.
Flexible Mushroom-Like Cross-Scale Surface with Extreme Pressure Resistance for Telecommunication Lines Anti-Icing/Deicing.
ACS Appl Mater Interfaces
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School of Manufacture Science and Engineering, Key Laboratory of Testing Technology for Manufacturing Process, Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, People's Republic of China.
Ice accretion caused by freezing rain or snowstorms is a common phenomenon in cold climates that seriously threatens the safety and reliability of telecommunication lines and other overhead networks. Various anti-icing strategies have been demonstrated through surface engineering to delay ice formation. However, existing anti-icing surfaces still encounter several challenges; for example, surfaces are prone to ice-pinning formation due to the impact of supercooled droplets, which leads to a loss of anti-icing effectiveness.
View Article and Find Full Text PDFHeating-Induced Redox Property Dynamics of Peat Soil Dissolved Organic Matter in a Simulated Peat Fire: Electron Exchange Capacity and Molecular Characteristics.
Environ Sci Technol
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Peatlands store one-third of the world's soil organic carbon. Globally increased fires altered peat soil organic matter chemistry, yet the redox property and molecular dynamics of peat-dissolved organic matter (PDOM) during fires remain poorly characterized, limiting our understanding of postfire biogeochemical processes. Clarifying these dynamic changes is essential for effective peatland fire management.
View Article and Find Full Text PDFSearching and Using MobiDB Resource 6 to Explore Predictions and Annotations for Intrinsically Disordered Proteins.
Curr Protoc
December 2024
Department of Biomedical Sciences, University of Padova, Padova, Italy.
Intrinsically disordered proteins (IDPs) make up around 30% of eukaryotic proteomes and play a crucial role in cellular processes and in pathological conditions such as neurodegenerative disorders and cancers. However, IDPs exhibit dynamic conformational ensembles and are often involved in the formation of biomolecular condensates. Understanding the function of IDPs is critical to research in many areas of science.
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