Ten new epipolythiodioxopiperazines (ETPs), namely, amphiepicoccins A-J (-), were isolated from the fish-gill-derived fungus HDN17-88. Their structures were deduced from extensive spectroscopic data and electronic circular dichroism (ECD) calculations. Amphiepicoccin A () which contains an aromatic indole motif is unprecedented among the epicoccin type of ETPs. Compounds , , and displayed anti-HSV-2 activities, with IC values of 70, 64, and 29 μM, respectively (acyclovir as positive control with an IC value of 31 μM), while and also revealed inhibitory activity against with minimum inhibitory concentration (MIC) values of 13 and 25 μM, respectively.
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Amphiepicoccins A-J: Epipolythiodioxopiperazines from the Fish-Gill-Derived Fungus HDN17-88.
J Nat Prod
February 2020
School of Medicine and Pharmacy , Ocean University of China, Qingdao 266003 , People's Republic of China.
Ten new epipolythiodioxopiperazines (ETPs), namely, amphiepicoccins A-J (-), were isolated from the fish-gill-derived fungus HDN17-88. Their structures were deduced from extensive spectroscopic data and electronic circular dichroism (ECD) calculations. Amphiepicoccin A () which contains an aromatic indole motif is unprecedented among the epicoccin type of ETPs.
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