AI Article Synopsis
- - The study investigates whether exposure to tobacco during prenatal and early childhood significantly raises the risk of developing pediatric psoriasis among children.
- - Findings indicate a 39% increased risk of pediatric psoriasis linked to prenatal smoke exposure, with higher risks associated with greater quantities of cigarettes smoked daily.
- - While prenatal exposure shows a strong correlation, the influence of tobacco exposure during infancy and childhood appears less significant after adjusting for prenatal factors.
Article Abstract
Background: Tobacco smoking is implicated in psoriasis among adults.
Objective: To determine whether prenatal, infantile, and childhood tobacco exposure increase risk of pediatric psoriasis.
Methods: Data from Danish National Birth Cohort participants were collected at approximately gestational week 12 and when the children were approximately 6 months and 11 years of age. In total, 25 812 offspring with complete data from the Danish National Birth Cohort were included. We estimated the odds of pediatric psoriasis with tobacco exposure prenatally, from birth to age 6 months (early infancy), and at age 11 years (childhood).
Results: We observed an increased risk of pediatric psoriasis among offspring with prenatal tobacco exposure (adjusted odds ratio [OR], 1.39; 95% confidence interval [CI], 1.06-1.82). An exposure-response relationship was observed for increasing quantities of cigarettes smoked daily (≥16 cigarettes: adjusted OR, 2.92; 95% CI, 1.20-7.10; P for trend = .038). The associations with infantile (adjusted OR, 1.17; 95% CI, 0.76-1.79) and childhood (adjusted OR, 1.10; 95% CI, 0.77-1.58) tobacco exposure were attenuated after controlling for prenatal exposure.
Limitations: Outcome status was maternally reported.
Conclusions: Prenatal tobacco exposure may increase the risk of pediatric psoriasis in a monotonic fashion, indicating that smoking may play a causal role in psoriasis pathogenesis.
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| http://dx.doi.org/10.1016/j.jaad.2019.09.038 | DOI Listing |
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