Joseph Martin and Tristan Free explore the latest developments in the T-cell-based therapy CAR-T and the challenges that need to be overcome for them to become common clinical practice.
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| http://dx.doi.org/10.2144/btn-2020-0001 | DOI Listing |
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Adaptations of neutrophils in cancer.
Immunity
January 2025
Vascular Biology and Therapeutics Program and Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Electronic address:
There is a renewed interest in neutrophil biology, largely instigated by their prominence in cancer. From an immunologist's perspective, a conceptual breakthrough is the realization that prototypical inflammatory, cytotoxic leukocytes can be tamed to promote the survival and growth of other cells. This has sparked interest in defining the biological principles and molecular mechanisms driving the adaptation of neutrophils to cancer.
View Article and Find Full Text PDFSetting a double-capacitive neuron coupled with Josephson junction and piezoelectric source.
Cogn Neurodyn
October 2024
Department of Physics, Lanzhou University of Technology, Lanzhou, 730050 China.
Perception of voice means acoustic electric conversion in the auditory system, and changes of external magnetic field can affect the neural activities by taming the channel current via some field components including memristor and Josephson junction. Combination of two capacitors via an electric component is effective to describe the physical property of artificial cell membrane, which is often used to reproduce the characteristic of electric activities in cell membrane. Involvement of two capacitive variables for two capacitors in the neural circuit can discern the effect of field diversity in the media in two sides of the cell membrane in theoretical way.
View Article and Find Full Text PDFSingle cell-spatial transcriptomics and bulk multi-omics analysis of heterogeneity and ecosystems in hepatocellular carcinoma.
NPJ Precis Oncol
November 2024
Department of Digestive Oncology, Guangxi Medical University Cancer Hospital, Nanning, China.
This study profiled global single cell-spatial-bulk transcriptome landscapes of hepatocellular carcinoma (HCC) ecosystem from six HCC cases and a non-carcinoma liver control donor. We discovered that intratumoral heterogeneity mainly derived from HCC cells diversity and pervaded the genome-transcriptome-proteome-metabolome network. HCC cells are the core driving force of taming tumor-associated macrophages (TAMs) with pro-tumorigenic phenotypes for favor its dominant growth.
View Article and Find Full Text PDFTAM-ing the beast with IL-34 blockade.
Sci Immunol
November 2024
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
mutation triggers IL-34 secretion by cancer stem cells, reprogramming macrophages to suppress T cells and promote tumor immune escape.
View Article and Find Full Text PDFElucidating the power of arginine restriction: taming type I interferon response in breast cancer via selective autophagy.
Cell Commun Signal
October 2024
Department of Biomedical Laboratory Science, Faculty of Natural Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Background: Type I interferons (IFN-I) are potent alarm factors that initiate cancer cell elimination within tumors by the immune system. This critical immune response is often suppressed in aggressive tumors, thereby facilitating cancer immune escape and unfavorable patient outcome. The mechanisms underpinning IFN-I suppression in tumors are incompletely understood.
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