The deuterium-tritium neutron generator is a common neutron source for fast neutron activation analysis. The 14.1 MeV neutrons emitted from a deuterium-tritium neutron generator are difficult to shield due to their strong penetrability and the induced secondary gamma rays in the shield. A rough calculation based on attenuation factors shows that when 14.1 MeV neutrons with a yield of 1 × 10 ns penetrate the designed shielding layers, which consist of a 0.5-m-thick concrete layer and a 0.5-m-thick water layer, the neutron ambient dose equivalent rate is 2.48 μSv h. A geometric model of a neutron shielding room is constructed based on the calculation. Monte Carlo simulations indicate that the highest neutron ambient dose equivalent rate outside the neutron shielding room is 0.73 μSv h, and the neutron ambient dose equivalent rate at the detector position in the shielding room is 2.12 μSv h. The experimental results show that the highest neutron ambient dose equivalent rate outside the neutron shielding room is 1.43 μSv h, and the neutron ambient dose equivalent rate at the detector position inside the shielding corridor is 2.74 μSv h. Comparative investigations show that the experimental results are basically consistent with the results of the Monte Carlo simulations, except for some positions with large proportions of fast neutrons where it is too difficult for the neutron dose equivalent meter to provide reliable values. Moreover, the radiation dose rate outside the designed shielding room is lower than the occupational exposure dose limit, which is in line with the design expectations. Finally, the gamma spectrum at the position of the gamma detectors is measured by a high-purity germanium detector. The analyzed results show that many secondary gamma rays are generated by the interaction of neutrons with the shield materials and detector probe crystals, and some gamma rays are produced from natural background radionuclides such as K, Tl, Bi, Bi, Pb, Pb, and Ac.
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http://dx.doi.org/10.1097/HP.0000000000001175 | DOI Listing |
BMJ Open
March 2025
School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Objectives: To describe the prevalence and patterns of opioid analgesic and pain medicine dispenses, and the impact of up-scheduling of low-dose (≤15 mg) codeine-containing products to Australians with accepted workers' compensation time loss claims for musculoskeletal conditions between 2010 and 2019.
Design: Interrupted time series.
Setting: Workers' compensation scheme in Victoria, Australia.
Food Chem Toxicol
March 2025
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, Shandong 264003, China. Electronic address:
Based on the concept of continuous dopaminergic stimulation (CDS), Rotigotine Behenate extended-release microspheres for injection (RBEM) are currently under development. To support human clinical trials of RBEM, a 20-week repeat-dose toxicity study was conducted. SD rats intramuscularly received RBEM (60, 180, and 540 mg/kg) once every 4 weeks for 5 repeated doses followed by a 12-week recovery period, no clear sex difference was noted in the plasma exposure of rotigotine in rats, and the exposure generally increased in a dose-proportional manner.
View Article and Find Full Text PDFPoult Sci
March 2025
INRAE, UMR ISP, Université de Tours, Nouzilly 37380, France. Electronic address:
Avian coccidiosis, caused by Eimeria spp., is the main parasitic disease in the poultry industry, responsible for high economic costs worldwide. Faced with anticoccidial resistance and societal pressure to reduce inputs in livestock sector, insects could provide a relevant alternative to anticoccidial molecules.
View Article and Find Full Text PDFSchizophr Res
March 2025
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, United States. Electronic address:
Background: P3a event-related potential (ERP) is considered a potential biomarker for schizophrenia (SZ), can be elicited through both passive two-stimulus and active three-stimulus auditory oddball paradigms. While both types of P3a reflect involuntary attention shifts, the nuanced understanding of what P3a represents in different contexts is important and rarely studied. This study aims to examine correlations between P3a ERPs elicited from different paradigms and associations of each P3a with cognitive function, clinical symptoms, and antipsychotic medication.
View Article and Find Full Text PDFJAMA Netw Open
March 2025
Department of Cardiovascular Medicine, St Luke's International Hospital, Tokyo, Japan.
Importance: Despite growing criticism of alcohol consumption due to its overall health risks, it remains unknown how changes in alcohol consumption, particularly cessation, affect lipid profiles outside of intense interventions.
Objective: To clarify the association of alcohol initiation and cessation with subsequent changes in low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
Design, Setting, And Participants: This cohort study included individuals undergoing annual checkups at a center for preventive medicine in Tokyo, Japan, from October 2012 to October 2022.
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