AI Article Synopsis
- The text discusses the synthesis of new isoxazole-containing 5' mRNA cap analogues through a cycloaddition reaction.
- These analogues can inhibit cap-dependent translation in lab conditions and utilize an isoxazolic ring for binding instead of guanine.
- The findings contribute to the development of potential anticancer treatments by informing the design of new compounds.
Article Abstract
Herein we describe a synthesis of new isoxazole-containing 5' mRNA cap analogues via a cycloaddition reaction. The obtained analogues show a capability to inhibit cap-dependent translation in vitro and are characterized by a new binding mode in which an isoxazolic ring, instead of guanine, is involved in the stacking effect. Our study provides valuable information toward designing new compounds that can be potentially used as anticancer therapeutics.
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| http://dx.doi.org/10.1016/j.bioorg.2020.103583 | DOI Listing |
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