AI Article Synopsis
- - The Ru(II)-catalyzed process aims to amidate 2-arylpyridines using aryl isocyanates through C-H bond activation.
- - This method has shown to be less effective than earlier reports because it generates multiple side products.
- - Advanced techniques like direct infusion electrospray mass spectrometry and high-performance liquid chromatography-mass spectrometry were used to identify these side products.
Article Abstract
The Ru(II)-catalyzed amidation of 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previously, due to the formation of a series of side products, which were readily identified using direct infusion electrospray mass spectrometry and high-performance liquid chromatography-mass spectrometry.
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| http://dx.doi.org/10.1021/acs.joc.9b02831 | DOI Listing |
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