Sclerosing angiomatoid nodular transformation of the spleen, a rare cause for splenectomy: Two case reports.

World J Clin Cases

Institute of Surgical Pathology, Medical Center-University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.

Published: January 2020

AI Article Synopsis

  • SANT is a rare but harmless disease that affects the spleen, but doctors aren't sure what causes it.
  • Two patients, a young man and an older woman, had symptoms that made doctors think they might have a serious problem, so they both had surgery to remove their spleens.
  • After surgery, doctors found out they both had SANT, and they are okay now, but more research is needed to understand how to find and treat SANT better.

Article Abstract

Background: Sclerosing angiomatoid nodular transformation (SANT) is a rare benign disease of the spleen with unknown origin. Clinical symptoms are inhomogeneous, and suspicious splenic lesion often found incidentally, leading to splenectomy, as malignancy cannot securely be ruled out. Diagnosis is made histologically after resection.

Case Summary: Two cases of German, white, non-smoking, and non-drinking patients of normal weight are presented. The first one is a 26-year-old man without medical history who was exhibiting an undesired weight loss of 10 kg and recurring vomiting for about 18 mo. The second one is a 65-year-old woman with hypertension who had previously undergone gynecological surgery, suffering from a lasting feeling of abdominal fullness. Both showed radiologically an inhomogeneous splenic lesion leading to splenectomy approximately 6 and 9 wk after surgical presentation. Both diagnoses of SANT were made histologically. Follow-up went well, and both were treated according to the recommendation for asplenic patients.

Conclusion: SANT is a rare cause of splenectomy and an incidental histological finding. Further research should focus on clinical and radiological diagnosis of SANT as well as on treatment of patients with asymptomatic and small findings.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962071PMC
http://dx.doi.org/10.12998/wjcc.v8.i1.103DOI Listing

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