Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1038/d41586-020-00094-5 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Thio-ProTide strategy: A novel HS donor-drug conjugate (DDC) alleviates hepatic injury innate lysosomal targeting.
Acta Pharm Sin B
December 2024
Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China.
Hydrogen sulfide (HS) is a gas signaling molecule with versatile bioactivities; however, its exploitation for disease treatment appears challenging. This study describes the design and characterization of a novel type of HS donor-drug conjugate (DDC) based on the thio-ProTide scaffold, an evolution of the ProTide strategy successfully used in drug discovery. The new HS DDCs achieved hepatic co-delivery of HS and an anti-fibrotic drug candidate named hydronidone, which synergistically attenuated liver injury and resulted in more sufficient intracellular drug exposure.
View Article and Find Full Text PDFThe Evolution of Nucleic Acid Nanotechnology: From DNA Assembly to DNA-Encoded Library.
Small Methods
January 2025
Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Innovative Drug Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing, 401331, China.
Deoxyribonucleic acid (DNA), a fundamental biomacromolecule in living organisms, serves as the carrier of genetic information. Beyond its role in encoding biological functions, DNA's inherent ability to hybridize through base pairing has opened new avenues for its application in biological sciences. This review introduces DNA nanotechnology and DNA-encoded library (DEL), and highlights their shared design principles related to DNA assembly.
View Article and Find Full Text PDFBioinspired Electrostatic Capture-and-Release System for Precise Microdroplet Manipulation.
Adv Mater
January 2025
Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing, 100083, China.
The application of physical fields is crucial for droplet generation and manipulation, underpinning technologies like printing, microfluidic biochips, drug delivery, and flexible sensors. Despite advancements, precise micro/nanoscale droplet generation and accurate microfluidic reactions remain challenging. Inspired by the liquid ejection mechanisms in microscopic organisms, an electrostatic manipulator for the precise capture, emission, and transport of microdroplets is proposed.
View Article and Find Full Text PDFPloidy levels influence cold tolerance of Cyclocarya paliurus: insight into the roles of WRKY genes.
BMC Genomics
January 2025
College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Cold stress in winter is one of the most severe abiotic stresses on plant growth and flourishing, and the selection of cold tolerant genotypes is an important strategy to ensure the safety of plant growth and development. Cyclocarya paliurus, a diclinous and versatile tree species originally in subtropical regions, has been introduced and cultivated in the warm temperate zone of China to meet the increasing market demand for its leaf yield. However, information regarding its cold tolerance remains limited.
View Article and Find Full Text PDFSilica Nanoparticles: A Promising Vehicle for Anti-Cancer Drugs Delivery.
AAPS PharmSciTech
January 2025
Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, 151001, India.
The prevalence and death due to cancer have been rising over the past few decades, and eliminating tumour cells without sacrificing healthy cells remains a difficult task. Due to the low specificity and solubility of drug molecules, patients often require high dosages to achieve the desired therapeutic effects. Silica nanoparticles (SiNPs) can effectively deliver therapeutic agents to targeted sites in the body, addressing these challenges.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!