Objective: Malignant insulinoma is an extremely uncommon tumor that is usually accompanied by severe hypoglycemia that is difficult to manage. At this time, the long-term effect of Lu-DOTATATE (lutetium [Lu-177]-DOTA-Tyr3-octreotate) on this tumor is not well known.
Methods: We report a case of severe, life-threatening, and refractory hypoglycemia associated with malignant insulinoma treated with Lu-DOTATATE.
Results: A 51-year-old woman was referred because of severe, life-threatening, and refractory hypoglycemia due to malignant insulinoma. The patient had been treated unsuccessfully with chemotherapy, targeted therapies, and symptomatic therapy with diazoxide, steroids, and somatostatin analogues without success. Lu-DOTATATE adequately controlled her hypoglycemia after the other conventional treatments failed.
Conclusion: Lu-DOTATATE was effective in providing rapid and long-term symptomatic control of the hypoglycemia and significantly improved the quality of life of the patient.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873842 | PMC |
| http://dx.doi.org/10.4158/ACCR-2019-0086 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[Salidroside alleviates high glucose and ethanol-induced pyroptosis in insulinoma cells].
Zhongguo Zhong Yao Za Zhi
November 2024
School of Pharmaceutical Sciences, Hubei University of Medicine Shiyan 442000, China Institute of Wudang Traditional Chinese Medicine, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China Department of Pharmacy, Taihe Hospital, Hubei University of Medicine Shiyan 442000, China.
This study established a pyroptosis injury model by stimulating insulinoma cells(INS-1) of rats with high glucose(HG) and observed the impact of additional ethanol(ET) exposure on cell pyroptosis, as well as the intervention effect of salidroside(SAL). INS-1 cells were cultured and divided into a normal control group(NG), an HG group, an HG + ET(100 mmol·L~(-1)) group, and an HG + ET + SAL(1-100 μmol·L~(-1)) group. After 72 hours of treatment, cell viability was assessed using the cell counting kit-8(CCK-8) assay.
View Article and Find Full Text PDFAggressive Metastatic Insulinoma in a Patient of Diabetes Mellitus with Documentation on Dual-Tracer PET-CT ([68Ga]Ga-DOTATATE and [18F]FDG): Clinical Benefits with Combined Chemo-PRRT Approach.
World J Nucl Med
December 2024
Radiation Medicine Centre, Bhabha Atomic Research Centre, Tata Memorial Hospital Annexe, Mumbai, Maharashtra, India.
Insulinoma is a relatively uncommon pancreatic neuroendocrine tumor, with approximately 10% of the cases being malignant. Diabetes mellitus (DM) with concurrent insulinoma is very rare and the diagnosis of such condition is easily missed as it can be misconstrued as improved glycemic control. Therefore, persistent hypoglycemic symptoms even after stopping antidiabetic medications may be considered for insulinoma.
View Article and Find Full Text PDFA Rare and Aggressive Case of Malignant Insulinoma.
Cureus
November 2024
Department of Internal Medicine, Centro Hospitalar Tondela-Viseu, Viseu, PRT.
Insulinomas are rare pancreatic neuroendocrine tumors (NETs) characterized by autonomous insulin secretion leading to hypoglycemia. Malignant insulinomas are defined by the presence of metastases and present significant therapeutic challenges due to limited treatment options. We report the case of a 69-year-old woman with a two-month history of neuroglycopenic symptoms, including morning headaches, blurred vision, palpitations, and sweating, which were alleviated by sugar intake.
View Article and Find Full Text PDFPancreatic β cell models for screening insulin secretagogues and cytotoxicity.
J Appl Toxicol
January 2025
Regenerative Medicine Laboratory, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.
In the past 2-3 decades, numerous attempts have been made to create an insulin-secreting β cell line that maintains normal insulin secretion. However, primary β cell cultures have finite life and, therefore, cannot be used for long-term experiments. The most widely used insulin-secreting cell lines are Insulinoma-1, rat insulinoma cell line, hamster pancreatic β cell line, mouse insulinoma, and β tumor cell line.
View Article and Find Full Text PDFExtra-adrenal adrenocortical cancer associated with multiple endocrine neoplasia type 1.
Endocrinol Diabetes Metab Case Rep
October 2024
Department of Endocrinology, Beaumont Hospital, Dublin, Ireland.
Summary: Adrenocortical carcinoma (ACC) is a rare malignant tumour arising from the adrenal cortex, with an estimated annual incidence of one to two patients per million. Ectopic ACCs are extremely rare. The majority of ACCs are sporadic; however, ACC has been linked with genetic disease processes, including multiple endocrine neoplasia type-1 (MEN-1).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!