Background And Objective: Bisphenol A (BPA) disturbs the metabolism in animals and humans through effecting endocrine system. The role of BPA in obesity is not studied well. Therefore, current study is conducted to investigate its association with childhood obesity.
Methods: Using gas chromatography-mass spectrometry (GC-MS/MS) serum BPA level was measured in 177 (120 normal and 57 obese) Saudi children.
Results: The analyses of the data revealed an elevated level of serum BPA, leptin, systolic blood pressure, triglyceride, insulin and vitamin D in obese children as compare to normal controls. An elevated serum BPA did not show association with increased vitamin D and insulin while positively associated with some of the key markers of obesity. BPA was also positively associated with laptin, insulin and diastolic blood pressure in individuals of both normal and obese groups but with little statistical differences.
Conclusion: Higher BPA level in obese children reveals that it may involve in the childhood obesity as it has shown a significant association with the key makers of the obesity in obese children especially in boys.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965998 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.
Metabolomics
January 2025
Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Background: Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.
View Article and Find Full Text PDFCombined Effects of Arsenic and Bisphenol-A on Locomotor Activity and Oxidative Stress Mediated Neurotoxicity in Mice.
Biol Trace Elem Res
January 2025
Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi-6205, Bangladesh.
Bisphenol A (BPA) is a monomer of plastic that can leach into water from scratched containers when used for an extended period. Arsenic (As) is an environmental toxicant, and people are exposed to both arsenic and BPA through drinking water and through scratched plastic containers used in contaminated areas. However, the combined effects of As and BPA on locomotor performance and neurobehavioral changes are yet to be investigated.
View Article and Find Full Text PDFPrenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring.
Front Endocrinol (Lausanne)
January 2025
Biomedical and Translational Sciences Institute, Neuroscience Division, Athens, GA, United States.
Significance: Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure during these times can impact brain development in the offspring, potentially leading to mood disorders in later life. Additionally, fluctuating levels of endogenous estrogens, as seen during pregnancy, or the use of oral contraceptives, can further elevate this risk.
View Article and Find Full Text PDFValidation of an in house iELISA for serodiagnosis of caprine brucellosis and evaluation of the performance of a B. neotomae lysate for the detection of anti-smooth Brucella specific antibodies in ruminants.
Vet Microbiol
January 2025
Instituto de Patobiología - Instituto de Patobiología Veterinaria (IP-IPVET), UEDD INTA-Conicet, Nicolás Repetto y de Los Reseros s/n (B1686), Hurlingham, Buenos Aires, Argentina; CONICET, Godoy Cruz 2290 (C1425FQB), CABA, Argentina. Electronic address:
Enzyme-linked immunosorbent assay (ELISA) is a widely used and effective tool for detection of anti-Brucella antibodies in serum, easy to perform with high sensitivity and specificity. In this study, we validated an in-house indirect ELISA using B. melitensis whole cell lysate as antigen (Bm-WCL iELISA) for the serodiagnosis of caprine brucellosis and evaluated the use of BSL-2 B.
View Article and Find Full Text PDFOxidative Stress and Keap1-Nrf2 Pathway Involvement in Bisphenol A-Induced Liver Damage in Rats.
Toxics
November 2024
College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Bisphenol A (BPA), extensively utilized in the manufacture of epoxy resins and polycarbonate plastics, is prevalent in the environment. Its exposure has been associated with an increased risk of hepatic lesions; however, the underlying mechanisms and the spectrum of its effects remain poorly understood. This study investigates the role of the Keap1-Nrf2 signaling pathway in regulating BPA-induced hepatotoxicity in vivo using a rat model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!