Effect of on migration, invasion and prognosis of prostate cancer.

Purpose: The present study was designed to explore the expression of sperm associated antigen 9 () in patients with prostate cancer and estimate the correlation between mRNA expression and prognosis of prostate cancer patients. Moreover, we also investigated the role of in migration and invasion of prostate cancer cell lines.

Methods: Quantitative real-time PCR (qRT-PCR) was adopted to detect the expression of mRNA in prostate cancer tissues. Chi-square was used to evaluate the relationship between expression and the clinical features of prostate cancer patients. Tranwell assay was performed to detect the migration and invasion of prostate cancer cells. Kaplan-Meier curve and Cox regression analysis were used to evaluate the prognostic value of in prostate cancer patients.

Results: The qRT-PCR results showed that mRNA was highly expressed in prostate cancer tissues than the control group (<0.05). There was tight relationship between mRNA expression and clinical characteristics such as Gleason score, NED rate and radical prostatectomy (<0.05). Overexpression of in vitro significantly promoted the migration and invasion of prostate cancer cells (<0.05). Kaplan-Meier survival analysis demonstrated that patients with high mRNA expression had higher mortality than those with low expression (<0.001). Both univariate and multivariate analyses revealed that was a prognostic factor for prostate cancer patients (=0.000, HR=4.878, 95% CI=2.422-9.825).

Conclusion: In a word, SPAG9 is a novel prognostic biomarker for prostate cancer patients.