Circulating microRNAs (miRNAs) are emerging as promising biomarkers for colorectal cancer (CRC). In this study, we sought to examine the diagnostic and prognostic role of serum miR-206 in CRC. A total of 73 CRC cases and 45 healthy control subjects were enrolled in this study. Quantitative reverse transcription PCR (qRT-PCR) was used to measure the relative serum miR-206 levels. Serum miR-206 levels were significantly decreased in CRC patients than normal controls. In addition, serum miR-206 demonstrated good diagnostic performance for discriminating CRC patients from healthy controls. miR-206 levels were increased in the blood samples of CRC patients who received surgery treatment. Moreover, serum miR-206 expression was closely associated with TNM stage and lymph node metastasis. CRC patients with low miR-206 level suffered more unfavorable overall survival and disease free survival compared to those with high miR-206 level. Furthermore, serum miR-206 was confirmed to be an independent prognostic indicator for CRC. In summary, serum miR-206 might be a promising biomarker for the diagnosis and prognosis of CRC.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965214 | PMC |
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