Background: hepatic steatosis including nonalcoholic fatty liver disease (NAFLD) has several same pathogenesis with inflammatory bowel disease (IBD) and the parenteral complication about NAFLD was reported rare. The aim of this study was to study the NAFLD incidence of IBD patients and influence factors.
Methods: we reviewed 137 patients with Crohn's disease (CD) and 69 patients with ulcerative colitis (UC). And 412 healthy controls with 2:1 ratio by gender, age, body mass index (BMI) were matched randomly to compare of nonalcoholic fatty liver disease (NAFLD) detective rate and analyzing other risk factors.
Results: the detective rate of NAFLD in CD was higher (10.95% vs. 4.01%, =0.006), while there was no difference in UC (10.14% vs. 9.42%, =0.868). CD patients with female, BMI normal or underweight had higher NAFLD incidence, while no difference was found in UC. With the increase of CRP, NAFLD detective rate of CD patients had a rising trend. In addition, BMI (=0.034), gender (=0.047), triglyceride (=0.026), LDL (=0.01) were high risk factors of NAFLD in CD. And GGT (=0.05), triglyceride (=0.032), VLDL (=0.043) were high risk factors in UC.
Conclusions: the incidence of NAFLD was high in CD but not in UC. By multi-factor variable analysis, we found that pathogenesis of NAFLD was closely related to BMI and CRP. This phenomenon may explain that malnutrition, intestinal endotoxemia are likely to be the leading cause of NAFLD in CD.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965779 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Mitochondrial dysfunction and lipid alterations in primary sclerosing cholangitis.
Scand J Gastroenterol
January 2025
Norwegian PSC Research Centre, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital Rikshospitalet, Oslo, Norway.
Objectives: Indications of mitochondrial dysfunction are commonly seen in liver diseases, but data are scarce in primary sclerosing cholangitis (PSC). Analyzing circulating and liver-resident molecules indirectly reflecting mitochondrial dysfunction, we aimed to comprehensively characterize this deficit in PSC, and whether this was PSC specific or associated with cholestasis.
Materials And Methods: We retrospectively included plasma from 191 non-transplant patients with large-duct PSC and 100 healthy controls and explanted liver tissue extracts from 24 PSC patients and 18 non-cholestatic liver disease controls.
Reduced portal vein blood flow velocity in acute fatty liver of pregnancy.
Front Med (Lausanne)
December 2024
Department of Medical Ultrasound, Jinshan Hospital of Fudan University, Shanghai, China.
Purpose: Acute fatty liver of pregnancy (AFLP) is a severe complication that can occur in the third trimester or immediately postpartum, characterized by rapid hepatic failure. This study aims to explore the changes in portal vein blood flow velocity and liver function during pregnancy, which may assist in the early diagnosis and management of AFLP.
Methods: This longitudinal study was conducted at a tertiary healthcare center with participants recruited from routine antenatal check-ups.
Machine learning applications in healthcare clinical practice and research.
World J Clin Cases
January 2025
Department of Gastroenterology, Laiko General Hospital, National and Kapodistrian University of Athens, Athens 11527, Greece.
Machine learning (ML) is a type of artificial intelligence that assists computers in the acquisition of knowledge through data analysis, thus creating machines that can complete tasks otherwise requiring human intelligence. Among its various applications, it has proven groundbreaking in healthcare as well, both in clinical practice and research. In this editorial, we succinctly introduce ML applications and present a study, featured in the latest issue of the .
View Article and Find Full Text PDFGut microbiota involvement in the effect of water-soluble dietary fiber on fatty liver and fibrosis.
Biosci Microbiota Food Health
August 2024
Department of Gastroenterology, Hematology and Clinical immunology, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki-shi, Aomori 036-8562, Japan.
The beneficial effects of water-soluble dietary fiber on liver fat and fibrosis involve the gut microbiota; however, few epidemiological studies have investigated this association. This large-scale epidemiological study aimed to determine the effect of water-soluble dietary fiber intake on liver fat and fibrosis via gut microbiota for the general population. We divided low- and high-intake groups by median daily water-soluble dietary fiber intake and matched background factors by propensity score matching for sex and age.
View Article and Find Full Text PDFComparative analysis of gut microbiota in metabolic syndrome and obese children from Southeastern China.
Front Microbiol
December 2024
Department of Pediatrics, Ningde Municipal Hospital of Ningde Normal University, Ningde, China.
The prevalence of childhood obesity is rising globally, with some obese children progressing to develop metabolic syndrome (MS). However, the specific differences between these groups remain unclear. To investigate the differences in gut microbiota, we conducted physiological and biochemical assessments, alongside 16S rRNA sequencing, in a cohort of 32 children from Southeastern China, which included 4 normal-weight children, 5 with mild obesity, 9 with moderate obesity, 9 with severe obesity, and 5 with metabolic syndrome.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!