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Nanoparticle technology has revolutionized breast cancer treatment by offering innovative solutions addressing the gaps in traditional treatment methods. This paper aimed to comprehensively explore the historical journey and advancements of nanoparticles in breast cancer treatment, highlighting their transformative impact on modern medicine. The discussion traces the evolution of nanoparticle-based therapies from their early conceptualization to their current applications and future potential.

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Targeted barcoding of variable antibody domains and individual transcriptomes of the human B-cell repertoire using Link-Seq.

PNAS Nexus

January 2025

Institute of Bioengineering, School of Engineering, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based on 3' barcoding of the transcriptome and subsequent single-molecule PCR in droplets, which freely shift the barcode along specific gene regions, such as the antibody heavy- and light-chain genes. Using the immune repertoire of COVID-19 patients and healthy donors as a model system, we obtain up to 91.

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Resistance training (RT) load and volume are considered crucial variables to appropriately prescribe and manage for eliciting the targeted acute responses (i.e., minimizing neuromuscular fatigue) and chronic adaptations (i.

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Interconnecting surgical science, art, philosophy and technology for holistic health.

J Ayurveda Integr Med

January 2025

Foundation for Ancient Indian Philosophy and Medicine, At 202, C.L.Magic, Prathamesh Coperative Housing society, Kondhwa Bk., Pune, 411048, Maharashtra, India. Electronic address:

Surgery is the branch of medicine which involves correction of the diseases by means of interventions and by means of various instruments and methods. Surgery in latin is called as Chirugi and in the Indian context it is termed as 'Shalyatantra'. Surgery is the science as well as the tantra or technology.

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This study explores the tensile performance of blind rivet joints in galvanized steel sheets, focusing on their behavior under shear and normal load conditions. Blind rivets are frequently used in structural applications due to their ease of installation and ability to be applied from one side, making them highly effective in industries like aerospace and automotive. Two types of DIN 7337-4.

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