AI Article Synopsis
- Hepatocellular carcinoma (HCC) is the most common type of liver cancer, making up about 90% of primary liver malignancies, but existing treatments only slightly extend survival times.
- Despite various therapies, the reasons behind HCC development and progression are still not well understood.
- This study analyzed the single-cell transcriptome of HCC samples and cell lines, revealing that the JunB proto-oncogene may play a role in immune responses and HCC progression, which could lead to new treatment options for patients.
Article Abstract
Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer, accounting for ~90% of all primary malignancy of the liver. Although various medical treatments have been used as systemic therapies, patient survival time may be extended by only a few months. Moreover, the underlying mechanisms of HCC development and progression remain poorly understood. In the present study, the single-cell transcriptome of one HCC tumor sample, two HCC cell lines and normal peripheral blood mononuclear cells were analysed in order to identify the potential mechanism underlying the development and progression of HCC. Interestingly, JunB proto-oncogene was identified to serve a role in the immune response and in development and progression of HCC, potentially contributing to the development of novel therapeutics for HCC patients.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6956120 | PMC |
| http://dx.doi.org/10.3892/ol.2019.11235 | DOI Listing |
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