AI Article Synopsis
- The study compares placebo responses in adults with ADHD using two assessment tools, TOVA and CAARS, to analyze data from a double-blind placebo-controlled trial.
- The TOVA-Attention Composite Score indicated the highest placebo response, highlighting differences in improvement variables when compared to results following methylphenidate treatment.
- A notable correlation was found between CAARS-PR and TOVA-PR, particularly in the Omissions score, suggesting that combining these assessments could enhance the evaluation of treatment responses in adults with ADHD.
Article Abstract
We compared the placebo response (PR) as measured by the Test of Variables of Attention (TOVA) and the Conners' Adult ADHD Rating Scale (CAARS) scores. A retrospective data analysis from a double-blind placebo-controlled study of metadoxine-ER in adults with ADHD. An additional database was used for comparison to TOVA response after methylphenidate challenge (TOVA-MPH-R). PR was highest when calculated from the TOVA-Attention Composite Score (ACS). The PR showed significantly fewer variables improving concomitantly compared with MPH-R. The most prominent correlation between the CAARS-PR and the TOVA-PR was in the Omissions score ( = .032), which was age-dependent ( = .0007, <.001). TOVA-PR has an index-specific profile compared with CAARS-PR and TOVA-MPH-R. The partial correlation of TOVA-PR with CAARS-PR suggests that a composite score of TOVA specific indices and CAARS could have a synergic impact to improve the reliability of the response assessment in adult ADHD.
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| http://dx.doi.org/10.1177/1087054719897819 | DOI Listing |
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