The 2014 NINDS Benchmarks for Epilepsy Research included area I: Understand the causes of the epilepsies and epilepsy-related neurologic, psychiatric, and somatic conditions. In preparation for the 2020 Curing Epilepsies Conference, where the Benchmarks will be revised, this review will cover scientific progress toward that Benchmark, with emphasize on studies since 2016.
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http://dx.doi.org/10.1177/1535759719895280 | DOI Listing |
Exp Anim
January 2025
Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia.
Status epilepticus is linked to cognitive decline due to damage to the hippocampus, a key structure involved in cognition. The hippocampus's high vulnerability to epilepsy-related damage is the main reason for this impairment. Convulsive seizures, such as those observed in status epilepticus, can cause various hippocampal pathologies, including inflammation, abnormal neurogenesis, and neuronal death.
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December 2024
Wolfson School of Medicine, University of Glasgow, Scotland, United Kingdom.
Background: Epilepsy poses significant challenges globally, with varied clinical, social, and economic impacts. Despite advances in treatment, epilepsy-related mortality remains a concern. This study aimed to analyze the demographic and regional distributions of epilepsy-related mortality in the United States (U.
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December 2024
Department of Neurology, Epilepsy Center, University of Pittsburgh Medical Center, Pittsburgh, PA, United States.
Purpose: Glymphatic function has not been explored in patients with focal cortical dysplasia (FCD)-related epilepsy. This study aimed to investigate the glymphatic system's involvement in these patients and to evaluate its correlation with response patterns to different antiseizure medications (ASMs) using diffusion tensor imaging along the perivascular space (DTI-ALPS).
Methods: Fifty-two patients with FCD-related epilepsy (10 with drug-responsive epilepsy and 42 with drug-resistant epilepsy) and 24 healthy controls (HC) were included.
Seizure
December 2024
University College Hospital, London, UK; UCL Queen Square Institute of Neurology: Department of Clinical and Experimental Epilepsy, London WC1N 3BG, UK. Electronic address:
Objective: Professional bodies recommend the use of performance validity tests (PVTs) to aid the interpretation of scores obtained in neuropsychological assessments, but base rates of failure differ according to neurological diagnosis and the associated impairments. This review summarises the PVT literature in people with epilepsy with the aim of establishing base rates of PVT failure and the factors associated with PVT performance in this population.
Methods: Ovid and PubMed databases were searched for studies reporting PVT test performance in people with epilepsy.
Epilepsia Open
January 2025
Faculty of Nursing, Atatürk University, Erzurum, Turkey.
Objective: This study was conducted to culturally adapt the Epilepsy-Related Apathy Scale in Adults with Epilepsy (E-RAS) to Turkish and to assess its psychometric properties in adult epilepsy patients.
Methods: A total of 172 epilepsy patients receiving care at the Neurology clinic and outpatient clinic of Fırat University Hospital from February to July 2023 were included in this methodological investigation. The E-RAS was translated into Turkish, and its content and construct validity were thoroughly examined.
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