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Influenza B virus infection alters the regenerative potential of murine alveolar type 2 pneumocytes.
mBio
December 2024
Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA.
Unlabelled: Respiratory epithelial cells can survive direct infection by influenza viruses, and the long-term consequences of that infection have been characterized in a subset of proximal airway cell types. The impact on the cells that survive viral infection in the distal lung epithelia, however, is much less well-characterized. Utilizing a Cre-expressing influenza B virus (IBV) and a lox-stop-lox tdTomato reporter mouse model, we identified that alveolar type 2 (AT2) pneumocytes, a progenitor cell type in the distal lung, can survive viral infection.
View Article and Find Full Text PDFPilot educational intervention for the care of adolescents with autism spectrum disorder during puberty.
J Am Assoc Nurse Pract
January 2025
Wegmans School of Nursing, St. John Fisher University, Rochester, New York.
Puberty is a particularly vulnerable time for individuals with autism spectrum disorder (ASD) during which baseline challenges are exacerbated, functioning often deteriorates, and additional barriers emerge. Specific concerns include increased vulnerability, decreased safety, and increased mood and behavioral disturbances. Youth with ASD need guidance and explicit instruction/skill development on topics such as hygiene/self-care, appropriate sexual activity, and menstruation management.
View Article and Find Full Text PDFAssociations Between Skeletal Alignment and Biomechanical Symmetry Before and After Transfemoral Bone-anchored Limb Implantation.
Clin Orthop Relat Res
December 2024
Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, USA.
Background: Patients with transfemoral amputation experience socket-related problems and musculoskeletal overuse injuries, both of which are exacerbated by asymmetric joint loading and alignment. Bone-anchored limbs are a promising alternative to treat chronic socket-related problems by directly attaching the prosthesis to the residual limb through an osseointegrated implant; however, it remains unknown how changes in alignment facilitated through a bone-anchored limb relate to loading asymmetry.
Questions/purposes: What is the association between femur-pelvis alignment and hip loading asymmetry during walking before and 12 months after transfemoral bone-anchored limb implantation?
Methods: Between 2019 and 2022, we performed 66 bone-anchored limb implantation surgeries on 63 individuals with chronic socket-related problems.
Preoperative patient teaching practices and associated factors among nurses working at hospitals in West Shoa Zone, Ethiopia, 2022: a cross-sectional study.
Front Public Health
January 2025
Department of Nursing, School of Nursing and Midwifery, Wallaga University, Nekemte, Ethiopia.
Introduction: Preoperative teaching is fundamental nursing activity in which a nurse educates the patient about surgery and what to anticipate following the procedure. It is a process via which nurses give standard preoperative information to patients before surgery, and it enables the patients to understand their diagnosis and treatment, actively participate in their own care, overcome feelings of incapacity in relation to their condition, regain health, and maintain home care. However, there is a dearth of studies that determine the extent of preoperative teaching practice in Ethiopia in general and in the study area in particular.
View Article and Find Full Text PDFDose-Response Effects of Exercise and Testosterone Replacement Therapy on Body Composition, Lean Mass, and Heart Rate Responses: A Case Report Using Wearable Technology.
Cureus
December 2024
College of Health Care Sciences, Nova Southeastern University, Fort Lauderdale, USA.
The case report explores the effects of testosterone replacement therapy (TRT) on body composition, lean muscle mass, and fat mass, based on the dosage of TRT and exercise intensity in a 40-year-old male. The purpose of this case study was to evaluate the dose-response relationship of TRT and exercise on muscle hypertrophy and fat loss over an eight-month period, using a validated wrist-worn wearable fitness tracker to measure daily physical activity and heart rate (HR)-based exercise intensity. The patient, a trained male with 25 years of consistent exercise experience, reported notable declines in strength and increases in body fat despite maintaining a regular workout routine.
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