AI Article Synopsis
- The study aimed to determine how common Hepatitis D virus (HDV) infections are among German blood donors who have previously been infected with Hepatitis B virus (HBV).
- Out of 167 tested donors, 5.4% showed signs of active HBV infection, while only 1.2% had detectable antibodies for HDV, indicating a low prevalence of HDV among this group.
- The results suggest that even though there may be a slightly higher prevalence in some cases, overall, HDV infections are relatively uncommon in Northern Germany.
Article Abstract
Objective: To assess the prevalence of HDV infections in German blood donors.
Method: 167 donors with acute/chronic or resolved HBV infection and detectable antibodies against Hepatitis B core antigen (anti-HBc) were tested for antibodies against HDV (anti-HDV) by competitive ELISA. Samples with detectable anti-HDV or with HBsAg and/or HBV DNA were additionally investigated for HDV RNA.
Results: In nine (5.4 %) of the 167 donors, also HBsAg and HBV DNA were detectable. Anti-HDV was detectable in two of the 167 donors (1.2 %), additional four donors (2.4 %) had a borderline result. All of these donors tested negative for HBsAg and HBV DNA. Neither in samples with anti-HDV nor in HBsAg-/HBV DNA-positive samples, HDV RNA was detectable.
Conclusions: At least 1.2 % of anti-HBc-positive blood donors have had an HDV infection. Although there is some evidence for a somewhat higher prevalence of HDV, the overall prevalence of HDV in Northern Germany is low.
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| http://dx.doi.org/10.1016/j.transci.2020.102721 | DOI Listing |
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