AI Article Synopsis
- The study focuses on creating and analyzing Ln complexes with a DOTA-based inhibitor designed to target matrix metalloproteinases.
- The presence of the Ln-DOTA component does not interfere with the inhibitor's strong binding to the enzyme's catalytic domain.
- The magnetic properties of the Ln complex are utilized to understand ligand-protein interactions and assess how variations in the linker length affect paramagnetic restraints.
Article Abstract
The design and synthesis of the Ln complexes of a DOTA-containing (DOTA=1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) inhibitor of matrix metalloproteinases are reported. The tight binding of the sulfonamide scaffold to the catalytic domain of the investigated matrix metalloproteinase is not impaired by the presence of the Ln -DOTA moiety. The paramagnetic properties of the Ln complex are exploited to obtain insights into the structural features of the ligand-protein interactions and to evaluate the influence of the linker length on the quality of the paramagnetic restraints.
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| http://dx.doi.org/10.1002/cplu.201600375 | DOI Listing |
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