serovar Kentucky (. Kentucky) sequence type 198 has emerged as a global zoonotic pathogen. We explored serovar Kentucky ST198 samples from the broiler chicken supply chain and patients between 2010 and 2016. Here, we collected 180 . Kentucky isolates from clinical cases and the poultry supply chain. We performed pulsed-field gel electrophoresis and multilocus sequence typing. We assessed mutations in the quinolone resistance-determining regions and screened for the presence of the genomic island 1 (SGI1). We determined that 63 (35.0%) of the 180 isolates were . Kentucky ST198. Chinese strains of . Kentucky ST198 have a high transmission of ciprofloxacin resistance (38/63, 60.3%) and a high risk of multidrug resistance. The quinolone resistance of the . Kentucky ST198 strain found in China may be due to mutations in its quinolone resistance-determining region. Our study firstly revealed that ciprofloxacin-resistant . Kentucky ST198 strains can undergo cross-host transmission, thereby causing a serious foodborne public health problem in China.
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| http://dx.doi.org/10.3390/microorganisms8010140 | DOI Listing |
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Background: The transmission of Salmonella spp. to human through the consumption of contaminated food products of animal origin, mainly poultry is a significant global public health concern. The emerging multidrug resistant (MDR) clones of non-typhoidal Salmonella (NTS) serovars, have spread rapidly worldwide both in humans and in the food chain.
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Prevalence and Genomic Characterization of Multidrug-Resistant Serovar Kentucky Sequence Type 198 Circulating - Beijing Municipality, China, 2016-2023.
China CDC Wkly
August 2024
Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning, Beijing Center for Disease Prevention and Control, Beijing, China.
Article Synopsis
- - The study focuses on a highly resistant strain of Salmonella Kentucky (ST198) that poses a global health threat due to its multidrug resistance, particularly against fluoroquinolones.
- - Researchers analyzed 54 Kentucky isolates from clinical and food sources in Beijing between 2016 and 2023 using genome sequencing and antibiotic testing, revealing various resistance patterns and mutations.
- - Findings show significant genetic diversity within the Kentucky population, highlighting the need for enhanced monitoring and control strategies to combat antimicrobial resistance (AMR) in both food and human health contexts.
Serovar and sequence type distribution and phenotypic and genotypic antimicrobial resistance of originating from pet animals in Chongqing, China.
Microbiol Spectr
July 2024
Laboratory of Veterinary Mycoplasmology, College of Veterinary Medicine, Southwest University, Chongqing, China.
A total of 334 isolates were recovered from 6,223 pet rectal samples collected at 50 pet clinics, 42 pet shops, 7 residential areas, and 4 plazas. Forty serovars were identified that included all strains except for one isolate that did not cluster via self-agglutination, with Typhimurium monophasic variant, Kentucky, Enteritidis, Pomona, and Give being the predominant serovars. Fifty-one sequence types were identified among the isolates, and ST198, ST11, ST19, ST451, ST34, and ST155 were the most common.
View Article and Find Full Text PDFPhenotypic and genomic characterization of a multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolated from a patient in China.
J Glob Antimicrob Resist
September 2024
Fujian Provincial Center for Disease Control and Prevention, Fuzhou 350011, China; Fujian Provincial Key Laboratory of Zoonosis Research, Fuzhou 350011, China; Fujian Institute of Preventive Medicine, Fuzhou, 350012, China. Electronic address:
Objectives: The objective of this study was to investigate the resistance mechanisms of a multidrug-resistant Salmonella Kentucky ST198 FJ-2064 isolated from a patient in China.
Methods: The antimicrobial susceptibility of FJ-2064 was determined by the standard disc dilution and broth microdilution methods. The complete genome of FJ-2064 was sequenced using PacBio and Illumina MiSeq platforms.
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