AI Article Synopsis
- * In a study involving one-day-old rats, those that experienced a heart attack showed a significant drop in heart function initially, but by three weeks, their heart function had returned to levels similar to those that did not have heart attacks.
- * The presence of new heart cells was confirmed in the injured area of the hearts, suggesting that newborn rats have a natural ability to grow new heart muscle after injury, which could one day help treat heart conditions in adults.
Article Abstract
Newborn mice and piglets exhibit natural heart regeneration after myocardial infarction (MI). Discovering other mammals with this ability would provide evidence that neonatal cardiac regeneration after MI may be a conserved phenotype, which if activated in adults could open new options for treating ischemic cardiomyopathy in humans. Here, we hypothesized that newborn rats undergo natural heart regeneration after MI. Using a neonatal rat MI model, we performed left anterior descending coronary artery ligation or sham surgery in one-day-old rats under hypothermic circulatory arrest (n = 74). Operative survival was 97.3%. At 1 day post-surgery, rats in the MI group exhibited significantly reduced ejection fraction (EF) compared to shams (87.1% vs. 53.0%, < 0.0001). At 3 weeks post-surgery, rats in the sham and MI groups demonstrated no difference in EF (71.1% vs. 69.2%, respectively, = 0.2511), left ventricular wall thickness ( = 0.9458), or chamber diameter ( = 0.7801). Masson's trichome and picrosirius red staining revealed minimal collagen scar after MI. Increased numbers of cardiomyocytes positive for 5-ethynyl-2'-deoxyuridine ( = 0.0072), Ki-67 ( = 0.0340), and aurora B kinase ( = 0.0430) were observed within the peri-infarct region after MI, indicating ischemia-induced cardiomyocyte proliferation. Overall, we present a neonatal rat MI model and demonstrate that newborn rats are capable of endogenous neocardiomyogenesis after MI.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017245 | PMC |
| http://dx.doi.org/10.3390/cells9010229 | DOI Listing |
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