AI Article Synopsis
- - The study aimed to determine how long after ovariectomy (OVX) in female rats the ability to regenerate alveolar bone is compromised.
- - Thirty-two female rats were divided into groups based on the time elapsed post-OVX (2M, 3M, and 4M), with defects created in their maxilla, and various analyses were done after euthanizing them at 2 and 4 weeks.
- - Results indicated that the 4M group had significantly poorer new bone formation and lower bone density compared to the other groups, establishing that 4 months post-OVX is the critical period for impaired bone regeneration.
Article Abstract
Background: The aim of this study was to seek the critical time for impairment of alveolar bone regeneration after ovariectomy (OVX) in rats.
Methods: A total of 32 female rats were used. Test group rats were divided into a 2M group (n = 8), a 3M group (n = 8) and a 4M group (n = 8) according to the duration from OVX to defect creation. Bilateral OVX was performed in all test groups, and a sham operation was performed in the control group (n = 8). Drill-hole defects (1.5 mm diameter, 2 mm length) were created on both sides of the maxilla. All rats were euthanized 2 and 4 weeks after the surgery. Microcomputed tomographic (micro-CT), histological, and histomorphometric analyses and in vitro experiments were performed.
Results: The 4M group showed significantly less new bone formation and a lower bone mineral density than the other groups in the micro-CT analysis. The histomorphometric analysis also revealed that the 4M group showed significantly less new bone formation than the control and 2M groups. The rats in the 4M group showed significantly higher alkaline phosphatase expression levels and a larger number of calcified nodules than rats in the other groups, whereas osteoclastic activity was significantly lower in the 4M group than in the other groups.
Conclusions: The critical time for impairment of alveolar bone regeneration was 4 months after OVX in rats.
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| http://dx.doi.org/10.1002/JPER.19-0537 | DOI Listing |
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