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| http://dx.doi.org/10.1111/all.14191 | DOI Listing |
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[Consensus for the treatment of atopic dermatitis in primary care: resolving myths and legends based on evidence].
Rev Alerg Mex
December 2024
Universidad Espíritu Santo, Samborondón, Guayas, Ecuador.
Article Synopsis
- Atopic dermatitis (AD) greatly affects patients' quality of life, and existing guidelines often target specialists instead of primary care physicians (PCPs).
- A study aimed to create a consensus document specifically for PCPs, offering evidence-based recommendations to enhance AD patient diagnosis and management.
- The document identifies obstacles PCPs face in implementing guidelines and provides consensus solutions to improve care for AD patients across different medical specialties.
Novel Scoring System for Ranking Hematopoietic Stem Cell Transplantation.
Clin Transplant
November 2024
Roswell Park Cancer Institute, Buffalo, New York, USA.
Background: When human leukocyte antigen (HLA)-matched donors are not available for hematopoietic stem cell transplants (HSCT), there are no well-accepted guidelines for ranking 7/8 HLA-matched unrelated donors to achieve optimal transplant outcomes. A novel scoring system for ranking HLA mismatches for these donors was investigated.
Methods: High-resolution HLA types were used to determine amino acid mismatches located in the HLA antigen-recognition domain.
SARS-CoV-2 infection induces hyaluronan production and hyaluronan levels in COVID-19 patients relate to morbidity and long-term lung impairment: a prospective cohort study.
mBio
October 2024
Department of Clinical Microbiology, Umeå University, Umeå, Sweden.
We previously demonstrated that the lungs of deceased COVID-19 patients were filled with a clear hydrogel consisting of hyaluronan (HA). In this translational study, we investigated the role of HA at all stages of COVID-19 disease to map the consequences of elevated HA on morbidity and identify the mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced HA production. A reduced alveolar surface area was observed in the lungs of deceased COVID-19 patients compared to healthy controls, as visualized by a 3D rendering of lung morphology using light-sheet fluorescence microscopy.
View Article and Find Full Text PDFSensitization against medical hyaluronidase in patients with confirmed hypersensitivity against hymenoptera species and its clinical implications.
Br J Dermatol
November 2024
Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, Munich, Germany, Frauenlobstr. 9-11, D-80337 Munich,Germany.
Background: Hyaluronidase is an ubiquitous enzyme, present, among others, in hymenoptera venom and in medical formulations. The latter include use as an emergency treatment or to correct undesired outcomes of medical and aesthetic procedures using hyaluronic acid fillers.
Objectives: By performing detailed allergy work-ups including skin-prick tests (SPTs) we investigated whether patients with a history of allergic reaction to hymenoptera venom are also sensitized to medical grade hyaluronidase.
A rare case of a huge malignant pleural mesothelioma presenting in the posterior mediastinum.
Respirol Case Rep
July 2024
Department of Respiratory Medicine, Allergy and Clinical Immunology Nagoya City University Graduate School of Medical Sciences Nagoya Japan.
We report a case of a 69-year-old woman with pleural mesothelioma presenting in the posterior mediastinum with a maximum diameter of 25 cm. She had a chronic cough and a pleural effusion was noted on chest X-ray. The examination of the effusion showed high hyaluronic acid levels, and mesothelioma was suspected.
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