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| http://dx.doi.org/10.1161/JAHA.119.013755 | DOI Listing |
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Plasma protein levels provide important insights into human disease, yet a comprehensive assessment of plasma proteomics across organs is lacking. Using large-scale multimodal data from the UK Biobank, we integrated plasma proteomics with organ imaging to map their phenotypic and genetic links, analyzing 2,923 proteins and 1,051 imaging traits across multiple organs. We uncovered 5,067 phenotypic protein-imaging associations, identifying both organ-specific and organ-shared proteomic relations, along with their enriched protein-protein interaction networks and biological pathways.
View Article and Find Full Text PDFContemporary Multi-modality Imaging of Prosthetic Aortic Valves.
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Section of Cardiovascular Imaging, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
With the aging of the general population and the rise in surgical and transcatheter aortic valve replacement, there will be an increase in the prevalence of prosthetic aortic valves. Patients with prosthetic aortic valves can develop a wide range of unique pathologies compared to the general population. Accurate diagnosis is necessary in this population to generate a comprehensive treatment plan.
View Article and Find Full Text PDFA Rare Case of a Cardiac Papillary Fibroelastoma Arising in the Right Atrial Septum and Resected via Minimally Invasive Cardiac Surgery.
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December 2024
Second Department of Surgery, Faculty of Medicine, Yamagata University, Yamagata, JPN.
Papillary fibroelastomas (PFEs) are rare, benign, primary cardiac tumors, typically found on the valve surfaces and more commonly on the left side of the heart, with occurrences in the right atrium even rarer. In this case, a highly mobile tumor was incidentally detected in the right atrium of an 83-year-old woman with advanced right lung cancer during preoperative transthoracic echocardiography and magnetic resonance imaging. Although the patient was asymptomatic and of advanced age, the tumor's high mobility warranted resection.
View Article and Find Full Text PDFEffects of transcutaneous auricular vagus nerve stimulation (taVNS) on motor planning: a multimodal signal study.
Cogn Neurodyn
December 2025
College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin, 300072 China.
Motor planning plays a pivotal role in daily life. Transcutaneous auricular vagus nerve stimulation (taVNS) has been demonstrated to enhance decision-making efficiency, illustrating its potential use in cognitive modulation. However, current research primarily focuses on behavioral and single-modal electrophysiological signal, such as electroencephalography (EEG) and electrocardiography (ECG).
View Article and Find Full Text PDF[Predictive model for ejection fraction improvement at one year in patients with acute ST-segment elevation myocardial infarction complicated with heart failure with reduced ejection fraction].
Zhonghua Yi Xue Za Zhi
January 2025
Ningbo Hangzhou Bay Hospital(Ningbo Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai),Ningbo315336, China.
To develop a predictive model for improvement of ejection fraction 1 year after heart failure with reduced ejection fraction (HFrEF) following acute ST-segment elevation myocardial infarction (STEMI). This nested case-control study included STEMI patients diagnosed with HFrEF from a prospective multicenter multimodality imaging cohort between August 2014 and March 2021. Based on the improvement of left ventricular ejection fraction (LVEF) at baseline and 1-year follow-up, the patients were classified into the heart failure with improved ejection fraction (HFimpEF) group and the persistent HFrEF group.
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