Background: Coronary artery disease is associated with unhealthy lifestyles such as smoking, lack of physical activity, and consuming an unhealthy diet. Other risk factors include family history and comorbidities such as hypertension, diabetes, smoking, obesity, and hypercholesterolemia.
Purpose: This study aims to investigate the effectiveness of mobile health care in improving the physiological index of patients with coronary artery disease.
Methods: This study used an experimental design. Convenience sampling was used to enroll 129 patients with coronary heart disease as participants, who were randomly assigned into the intervention group (n = 64) and control group (n = 65). The intervention group participants received a 12-week mobile health care intervention, while the control group participants received routine care in the outpatient department. The physiological index outcome variables included body mass index (BMI), lipid profile, and blood pressure. Data were analyzed using generalized estimating equation curve analysis.
Results: The mean triglyceride (TG) reduction value after the intervention in the experimental group was significantly higher (reduction of 39.27 mg/dl; p < .05) than in the control group. Moreover, mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) reduction values in the experimental group were significantly higher (reductions of 8.32 mmHg and 4.24 mmHg; p < .01) than in the control group. Furthermore, the mean reduction in BMI value in the experimental group was significantly higher (reduction of 0.48 Kg/m; p < .05) than in the control group. Finally, only the mean reduction in low density lipoprotein (LDL) values was greater (by 1.11 mg/dl) in the experimental group than in the control group. However, this reduction did not reach statistical significance.
Conclusions: Mobile health care has the potential to reduce TG, blood pressure, and BMI in patients with coronary artery disease.
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http://dx.doi.org/10.6224/JN.202002_67(1).09 | DOI Listing |
Ocul Immunol Inflamm
January 2025
Ocular Oncology Service, Institute of Oncology, Tecnologico de Monterrey, Monterrey, Mexico.
Purpose: To present the case of a young patient with BRAF V600E-mutant cutaneous melanoma who developed bilateral choroidal metastases complicated by neovascular glaucoma (NVG) in both eyes following the interruption of nivolumab therapy.
Methods: A 28-year-old female with primary cutaneous melanoma of the left hand underwent surgical resection and adjuvant nivolumab. Immunotherapy was discontinued due to immune-related acute interstitial nephritis.
Front Biosci (Landmark Ed)
January 2025
Department of Neurology, Jinshan Hospital, Fudan University, 201508 Shanghai, China.
Background: Neuronal cholesterol deficiency may contribute to the synaptopathy observed in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. Intact synaptic vesicle (SV) mobility is crucial for normal synaptic function, whereas disrupted SV mobility can trigger the synaptopathy associated with AD.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Department of Obstetrics and Gynecology, Zhongda Hospital, School of Medicine, Southeast University, 210000 Nanjing, Jiangsu, China.
Background: Pre-eclampsia (PE) is a gestational disorder that significantly endangers maternal and fetal health. Transfer ribonucleic acid (tRNA)-derived small RNAs (tsRNAs) are important in the progression and diagnosis of various diseases. However, their role in the development of PE is unclear.
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Division of Molecular Psychiatry, Center of Mental Health, University of Hospital Würzburg, 97080 Würzburg, Germany.
Background: The inheritance of the short allele, encoding the serotonin transporter (SERT) in humans, increases susceptibility to neuropsychiatric and metabolic disorders, with aging and female sex further exacerbating these conditions. Both central and peripheral mechanisms of the compromised serotonin (5-HT) system play crucial roles in this context. Previous studies on SERT-deficient (Sert) mice, which model human SERT deficiency, have demonstrated emotional and metabolic disturbances, exacerbated by exposure to a high-fat Western diet (WD).
View Article and Find Full Text PDFFront Biosci (Landmark Ed)
January 2025
Department of Zoology, College of Science, King Saud University, 11451 Riyadh, Saudi Arabia.
Background: We investigated chitosan's protective effects against tertiary butylhydroquinone (TBHQ)-induced toxicity in adult male rats, focusing on cognitive functions and oxidative stress in the brain, liver, and kidneys.
Methods: Rats were divided into four groups (n = 8/group): (1) Control, (2) Chitosan only, (3) TBHQ only, and (4) Chitosan + TBHQ.
Results: TBHQ exposure led to significant cognitive impairments and increased oxidative stress, marked by elevated malondialdehyde (MDA) and decreased superoxide dismutase (SOD) and glutathione (GSH) levels.
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