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An international update of the EORTC questionnaire for assessing quality of life in breast cancer patients: EORTC QLQ-BR45. | LitMetric

AI Article Synopsis

  • The EORTC QLQ-BR23, initially developed in 1996 to evaluate quality of life in breast cancer patients, needed an update due to significant treatment advancements.
  • A systematic review identified 83 quality of life issues, leading to the creation of 27 items after consultations with patients and health providers, and these were tested in an international study with 250 participants from 12 countries.
  • The updated version, now called the EORTC QLQ-BR45, features 45 items including new scales for target symptoms and treatment satisfaction, enhancing the assessment of breast cancer treatment impacts on patient quality of life.

Article Abstract

Background: The European Organization for Research and Treatment of Cancer (EORTC) QLQ-BR23 was one of the first disease-specific questionnaires developed in 1996 to assess quality of life (QoL) in patients with breast cancer (BC). However, since 1996 major changes in BC treatment have occurred, requiring an update of the EORTC BC module. This study presents the results of the phase I-III update of the QLQ-BR23 questionnaire.

Patients And Methods: The update of the EORTC QLQ-BR23 module followed standard EORTC guidelines. A systematic literature review revealed 83 potential relevant QoL issues during phases I and II. After shortening the issues list and following interviews with patients and health care providers, 15 relevant issues were transformed into 27 items. The preliminary module was pretested in an international, multicentre phase III study to identify and solve potential problems with wording comprehensibility and acceptability of the items. Descriptive statistics are provided. Analyses were qualitative and quantitative. We provide a psychometric structure of the items.

Results: The phase I and II results indicated the need to supplement the original QLQ-BR23 with additional items related to newer therapeutic options. The phase III study recruited a total of 250 patients (from 12 countries). The final updated phase III module contains a total of 45 items: 23 items from the QLQ-BR23 and 22 new items. The new items contain two multi-item scales: a target symptom scale and a satisfaction scale. The target symptom scale can be divided into three subscales: endocrine therapy, endocrine sexual and skin/mucosa scale.

Conclusion: Our work has led to the development of a new EORTC QLQ-BR45 module that provides a more accurate and comprehensive assessment of the impact of new and scalable treatments on patients' QoL. The final version of the EORTC QLQ-BR45 is currently available for use in clinical practice. The final phase IV study is underway to confirm psychometric properties of the module.

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Source
http://dx.doi.org/10.1016/j.annonc.2019.10.027DOI Listing

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