AI Article Synopsis
- Medication-induced hyperglycemia is a common issue in children, with a review aiming to inform healthcare providers about preventive and management strategies.
- Many medications causing hyperglycemia in adults also affect children, but specific data on this is limited.
- Understanding how these medications work and recognizing patient risk factors can help improve outcomes for affected pediatric patients.
Article Abstract
Medication-induced hyperglycemia is a frequently encountered clinical problem in children. The intent of this review of medications that cause hyperglycemia and their mechanisms of action is to help guide clinicians in prevention, screening and management of pediatric drug-induced hyperglycemia. We conducted a thorough literature review in PubMed and Cochrane libraries from inception to July 2019. Although many pharmacotherapies that have been associated with hyperglycemia in adults are also used in children, pediatric-specific data on medication-induced hyperglycemia are scarce. The mechanisms of hyperglycemia may involve β cell destruction, decreased insulin secretion and/or sensitivity, and excessive glucose influx. While some medications (eg, glucocorticoids, L-asparaginase, tacrolimus) are markedly associated with high risk of hyperglycemia, the association is less clear in others (eg, clonidine, hormonal contraceptives, amiodarone). In addition to the drug and its dose, patient characteristics, such as obesity or family history of diabetes, affect a child's risk of developing hyperglycemia. Identification of pediatric patients with increased risk of developing hyperglycemia, creating strategies for risk reduction, and treating hyperglycemia in a timely manner may improve patient outcomes.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954773 | PMC |
| http://dx.doi.org/10.1136/bmjdrc-2019-000801 | DOI Listing |
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Article Synopsis
- Medication-induced hyperglycemia is a common issue in children, with a review aiming to inform healthcare providers about preventive and management strategies.
- Many medications causing hyperglycemia in adults also affect children, but specific data on this is limited.
- Understanding how these medications work and recognizing patient risk factors can help improve outcomes for affected pediatric patients.
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