Background: The use of electrocautery (EC)-facilitated re-entry in an aorto-ostial chronic total occlusion (CTO) of the right coronary artery (RCA) was first described in 2016. Since then, it has been utilized sporadically, but little is reported about the use of EC in lesion crossing during CTO percutaneous coronary intervention (PCI). The objective of this study is to describe the efficacy of EC-facilitated crossing (ECFC) of CTOs.
Methods: We report a case series of ECFC of CTOs where standard techniques are either not suitable or ineffective. We utilized stiff, high tip-load, and tapered guidewires energized with EC to facilitate wire crossing of wire-uncrossable CTOs.
Results: A total of 293 CTO-PCIs were performed at our institution between October 16, 2016 and October 30, 2018 and ECFC was attempted in 6 cases (2%); 5 cases were retrograde and 1 case was both antegrade and retrograde. All 6 cases were classified as very difficult by the J-CTO score of ≥3. ECFC was performed in 2 aorto-ostial lesions, 3 lesions at the major bifurcation, and 1 lesion in the proximal obtuse marginal. The successful crossing of the target lesion was achieved using ECFC in 5 cases (83%). We were unable to cross 1 lesion of severe in-stent restenosis with stent fracture at the distal RCA bifurcation. Despite attempting ECFC, both antegrade and retrograde crossing remained unsuccessful. There were no ECFC-related complications.
Conclusion: The use of energized stiff guidewires to perform ECFC can be of great value for CTO lesions when standard CTO techniques fail. ECFC should only be performed with caution by experienced and high-volume operators to avoid complications.
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http://dx.doi.org/10.25270/jic/19.00260 | DOI Listing |
Abdom Radiol (NY)
December 2024
Mayo Clinic, Rochester, USA.
Purpose: To evaluate correlation between terminal ileal (TI) stricture diagnosis at MR enterography (MRE) and ileocolonoscopy (IC) in patients with Crohn's disease (CD).
Methods: One hundred and four patients with CD (51% females; 41 ± 15 years) underwent IC and MRE within 3 months in this retrospective case-control study. Positive cases had TI strictures diagnosed by endoscopy (n = 35); or MRE (threshold small bowel dilation ≥ 3cm; n = 34).
Stem Cell Rev Rep
November 2024
INSERM U935/U1310 ESTeam Paris Sud Human Pluripotent Stem Cell Core Facility, Villejuif, France.
The discovery of endothelial progenitor cells has revolutionized our understanding of postnatal blood vessel formation, with endothelial colony-forming cells (ECFCs) emerging as key players in vasculogenesis. Among various ECFC sources, cord blood-derived ECFCs (CB-ECFCs) are of particular interest due to their superior proliferative and clonogenic potential and their ability to promote vascular network formation. Human embryonic stem cell-derived endothelial cells (hESC-ECs) have also shown potential in regenerative medicine, though their vasculogenic efficacy remains unclear compared to CB- and adult blood-derived ECFCs (AB-ECFCs).
View Article and Find Full Text PDFJ Thromb Haemost
November 2024
Department of Hematology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:
Background: von Willebrand disease (VWD) is the most common inherited bleeding disorder caused by quantitative or qualitative defects in von Willebrand factor (VWF). The p.M771V VWF variant leads to a severe bleeding phenotype in homozygous patients.
View Article and Find Full Text PDFNutrients
September 2024
Cell Transplant Center, Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Background: Managing metabolism for optimal training, performance, and recovery in medium-to-high-level endurance runners involves enhancing energy systems through strategic nutrient intake. Optimal carbohydrate intake before, during, and after endurance running can enhance glycogen stores and maintain optimal blood glucose levels, influencing various physiological responses and adaptations, including transitory post-endurance inflammation. This randomized trial investigates the impact of a high-dose 2:1 maltodextrin-fructose supplementation to medium-to-high-level endurance runners immediately before, during, and after a 15 km run at 90% VO intensity on post-exercise inflammatory stress.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
July 2024
Regenerative Medicine Institute (REMEDI), Biomedical Sciences Building, University of Galway, Galway, Ireland.
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia, leading to various vascular complications. Accumulating evidence indicates that endothelial colony-forming cells (ECFCs) have attractive prospects for repairing and restoring blood vessels. Thus, ECFCs may be a novel therapeutic option for diabetic patients with vascular complications who require revascularization therapy.
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